ArticleEndocrine2005
Androgen-receptor coregulators mediate the suppressive effect of androgen signals on vitamin D receptor activity.
Article in Endocrine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Role of PRMT5 in regulating ferritinophagy during Mycobacterium tuberculosis infection.PLoS pathogens · 2026Article
- The emerging role of nuclear receptor coactivator 4 in health and disease: a novel bridge between iron metabolism and immunity.Cell death discovery · 2024Review
- Gender, hyperandrogenism and vitamin D deficiency related functional and morphological alterations of rat cerebral arteries.PloS one · 2019Article
- The Role of NCOA4-Mediated Ferritinophagy in Health and Disease.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Expression and function of nuclear receptor coactivator 4 isoforms in transformed endometriotic and malignant ovarian cells.Oncotarget · 2018Article
- Generation and characterization of monoclonal antibodies that recognize human and murine supervillin protein isoforms.PloS one · 2018Article
- LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer.Clinical epigenetics · 2017Article
- Association of vitamin D receptor variants with clinical parameters in prostate cancer.SpringerPlus · 2016Article
- Calcitriol in Combination Therapy for Prostate Cancer: Pharmacokinetic and Pharmacodynamic Interactions.Journal of Cancer · 2016Review
- 1,25-Dihydroxyvitamin D3 increases testosterone-induced 17beta-estradiol secretion and reverses testosterone-reduced connexin 43 in rat granulosa cells.Reproductive biology and endocrinology : RB&E · 2014Article
- RBR E3 ubiquitin ligases: new structures, new insights, new questions.The Biochemical journal · 2014Review
- Structural considerations of vitamin D signaling.Frontiers in physiology · 2014Review
- Interaction of vitamin D with membrane-based signaling pathways.Frontiers in physiology · 2014Review
- Role of androgen and vitamin D receptors in endothelial cells from benign and malignant human prostate.American journal of physiology. Endocrinology and metabolism · 2013Review
- Expression and function of nuclear receptor co-activator 4: evidence of a potential role independent of co-activator activity.Cellular and molecular life sciences : CMLS · 2012Review
- Research resource: interplay between the genomic and transcriptional networks of androgen receptor and estrogen receptor α in luminal breast cancer cells.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Vitamin D resistance and colon cancer prevention.Carcinogenesis · 2012Review
- A cell model for conditional profiling of androgen-receptor-interacting proteins.International journal of endocrinology · 2012Article
- Dietary vitamin D and vitamin D receptor level modulate epithelial cell proliferation and apoptosis in the prostate.Cancer prevention research (Philadelphia, Pa.) · 2011Article
- Dynamic distribution of nuclear coactivator 4 during mitosis: association with mitotic apparatus and midbodies.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overexpression of androgen receptors (AR) in PC-3 cell, and treatment of 5alpha-dihydrotestosterone in LNCaP cells lead to the suppression of VDR transactivation. Competition for shared coregulators between AR and VDR is one possible mechanism to explain the suppressive effect of androgen-AR signals on VDR activity. Among the AR coregulators we tested, ARA54, ARA70, supervillin, and gelsolin were found to enhance VDR transactivation. Further characterization of the interaction between ARA54 or ARA70 and VDR demonstrated a direct interaction between VDR and ARA70, but no association between ARA54 and VDR. The LXXLL motif of ARA70 is essential for interaction with VDR and partially responsible for its function as a coactivator of VDR. The suppression of VDR transactivation by AR signal was restored by overexpression of ARA70, but not ARA54. Together, ARA70 and ARA54 modulate VDR transactivation, and the competition for ARA70 mediates the suppressive effect of androgen-AR on VDR transactivation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.