ArticleJournal of bacteriology2005
Genetic and structural analysis of the Bacteroides conjugative transposon CTn341.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Antimicrobial resistance is widespread among intestinal and extra-intestinalInfection and immunity · 2025Article
- Genomic repertoires linked with pathogenic potency of arthritogenicAnnals of the rheumatic diseases · 2023Article
- ggMOB: Elucidation of genomic conjugative features and associated cargo genes across bacterial genera using genus-genus mobilization networks.Frontiers in genetics · 2022Article
- Mobilization of vitamin BCell reports · 2021Article
- Mobile Type VI secretion system loci of the gut Bacteroidales display extensive intra-ecosystem transfer, multi-species spread and geographical clustering.PLoS genetics · 2021Article
- Streamlined Genetic Manipulation of DiversemBio · 2019Article
- Novel large-scale chromosomal transfer in Bacteroides fragilis contributes to its pan-genome and rapid environmental adaptation.Microbial genomics · 2017Article
- Extensive Mobilome-Driven Genome Diversification in Mouse Gut-Associated Bacteroides vulgatus mpk.Genome biology and evolution · 2016Article
- The Ellis Island Effect: A novel mobile element in a multi-drug resistantMobile genetic elements · 2014Article
- Regulation of CTnDOT conjugative transfer is a complex and highly coordinated series of events.mBio · 2013Review
- Genetic diversity in the oral pathogen Porphyromonas gingivalis: molecular mechanisms and biological consequences.Future microbiology · 2013Review
- Gliding motility and Por secretion system genes are widespread among members of the phylum bacteroidetes.Journal of bacteriology · 2013Article
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- Different genetic supports for the tet(S) gene in Enterococci.Antimicrobial agents and chemotherapy · 2012Article
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- Mobile genetic elements in the genus Bacteroides, and their mechanism(s) of dissemination.Mobile genetic elements · 2011Article
- Genetic and functional analyses of the mob operon on conjugative transposon CTn341 from Bacteroides spp.Journal of bacteriology · 2010Article
- Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis.DNA research : an international journal for rapid publication of reports on genes and genomes · 2008Article
- Interaction of Bacteroides fragilis pLV22a relaxase and transfer DNA with Escherichia coli RP4-TraG coupling protein.Molecular microbiology · 2007Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The genetic structure and functional organization of a Bacteroides conjugative transposon (CTn), CTn341, were determined. CTn341 was originally isolated from a tetracycline-resistant clinical isolate of Bacteroides vulgatus. The element was 51,993 bp long, which included a 5-bp coupling sequence that linked the transposon ends in the circular form. There were 46 genes, and the corresponding gene products fell into three major functional groups: DNA metabolism, regulation and antibiotic resistance, and conjugation. The G + C content and codon usage observed in the functional groups suggested that the groups belong to different genetic lineages, indicating that CTn341 is a composite, modular element. Mutational analysis of genes representing the different functional groups provided evidence for the gene assignments and showed that the basic conjugation and excision genes are conserved among Bacteroides spp. A group IIA1 intron, designated B.f.I1, was found to be inserted into the bmhA methylase gene. Reverse transcriptase PCR analysis of CTn341 RNA showed that B.fr.I1 was functional and was spliced out of the bmhA gene. Six related CTn-like elements were found in the genome sequences of Bacteroides fragilis NCTC9343 and Bacteroides thetaiotaomicron VPI5482. The putative elements were similar to CTn341 primarily in the tra and mob regions and in the exc gene, and several appeared to contain intron elements. Our data provide the first reported sequence for a complete Bacteroides CTn, and they should be of considerable benefit to further functional and genetic analyses of antibiotic resistance elements and genome evolution in Bacteroides.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.