ArticleJournal of bacteriology2005
Antimutator role of DNA glycosylase MutY in pathogenic Neisseria species.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Inhibitors of DNA Glycosylases as Prospective Drugs.International journal of molecular sciences · 2020Review
- Activity of Vsr endonucleases encoded by Neisseria gonorrhoeae FA1090 is influenced by MutL and MutS proteins.BMC microbiology · 2018Article
- A Mutator Phenotype Promoting the Emergence of Spontaneous Oxidative Stress-Resistant Mutants in Campylobacter jejuni.Applied and environmental microbiology · 2017Article
- Article
- The BER necessities: the repair of DNA damage in human-adapted bacterial pathogens.Nature reviews. Microbiology · 2015Review
- How the Knowledge of Interactions between Meningococcus and the Human Immune System Has Been Used to Prepare Effective Neisseria meningitidis Vaccines.Journal of immunology research · 2015Review
- Molecular characterization of Rifr mutations in Enterococcus faecalis and Enterococcus faecium.Journal of chemotherapy (Florence, Italy) · 2014Article
- Role of DNA base excision repair in the mutability and virulence of Streptococcus mutans.Molecular microbiology · 2012Article
- Three nth homologs are all required for efficient repair of spontaneous DNA damage in Deinococcus radiodurans.Extremophiles : life under extreme conditions · 2012Article
- A network of enzymes involved in repair of oxidative DNA damage in Neisseria meningitidis.Molecular microbiology · 2012Article
- A bacterial siren song: intimate interactions between Neisseria and neutrophils.Nature reviews. Microbiology · 2012Review
- The Presence of the DNA Repair Genes mutM, mutY, mutL, and mutS is Related to Proteome Size in Bacterial Genomes.Frontiers in genetics · 2012Article
- Porphyromonas gingivalis mutY is involved in the repair of oxidative stress-induced DNA mispairing.Molecular oral microbiology · 2011Article
- Resistance of Neisseria gonorrhoeae to neutrophils.Frontiers in microbiology · 2011Article
- Mismatch correction modulates mutation frequency and pilus phase and antigenic variation in Neisseria gonorrhoeae.Journal of bacteriology · 2010Article
- Use of nfsB, encoding nitroreductase, as a reporter gene to determine the mutational spectrum of spontaneous mutations in Neisseria gonorrhoeae.BMC microbiology · 2009Article
- Genetic interactions of DNA repair pathways in the pathogen Neisseria meningitidis.Journal of bacteriology · 2007Article
- The outer membrane secretin PilQ from Neisseria meningitidis binds DNA.Microbiology (Reading, England) · 2007Article
- AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis.The EMBO journal · 2007Article
- Role of a MutY DNA glycosylase in combating oxidative DNA damage in Helicobacter pylori.DNA repair · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome alterations due to horizontal gene transfer and stress constantly generate strain on the gene pool of Neisseria meningitidis, the causative agent of meningococcal (MC) disease. The DNA glycosylase MutY of the base excision repair pathway is involved in the protection against oxidative stress. MC MutY expressed in Escherichia coli exhibited base excision activity towards DNA substrates containing A:7,8-dihydro-8-oxo-2'-deoxyguanosine and A:C mismatches. Expression in E. coli fully suppressed the elevated spontaneous mutation rate found in the E. coli mutY mutant. An assessment of MutY activity in lysates of neisserial wild-type and mutY mutant strains showed that both MC and gonococcal (GC) MutY is expressed and active in vivo. Strikingly, MC and GC mutY mutants exhibited 60- to 140-fold and 20-fold increases in mutation rates, respectively, compared to the wild-type strains. Moreover, the differences in transitions and transversions in rpoB conferring rifampin resistance observed with the wild type and mutants demonstrated that the neisserial MutY enzyme works in preventing GC-->AT transversions. These findings are important in the context of models linking mutator phenotypes of disease isolates to microbial fitness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.