ArticleGenome research2005
Ancient haplotypes resulting from extensive molecular rearrangements in the wheat A genome have been maintained in species of three different ploidy levels.
Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 70 citations in OpenAlex.
- Characterization and Use in Wheat Breeding of Leaf Rust Resistance Genes from Durable Varieties.Biology · 2021Article
- The NLR-Annotator Tool Enables Annotation of the Intracellular Immune Receptor Repertoire.Plant physiology · 2020Article
- Cloning of the wheat Yr15 resistance gene sheds light on the plant tandem kinase-pseudokinase family.Nature communications · 2018Article
- Impact of transposable elements on genome structure and evolution in bread wheat.Genome biology · 2018Article
- Chromosome-scale comparative sequence analysis unravels molecular mechanisms of genome dynamics between two wheat cultivars.Genome biology · 2018Article
- Impact of transposable elements on polyploid plant genomes.Annals of botany · 2017Review
- Effects of ploidy level and haplotype on variation of photosynthetic traits: Novel evidence from two Fragaria species.PloS one · 2017Article
- Suppressed recombination and unique candidate genes in the divergent haplotype encoding Fhb1, a major Fusarium head blight resistance locus in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
- Simulating Next-Generation Sequencing Datasets from Empirical Mutation and Sequencing Models.PloS one · 2016Article
- Zn2+ blocks annealing of complementary single-stranded DNA in a sequence-selective manner.Scientific reports · 2014Article
- Article
- Sequence-based mapping of the polyploid wheat genome.G3 (Bethesda, Md.) · 2013Article
- Separating homeologs by phasing in the tetraploid wheat transcriptome.Genome biology · 2013Article
- Genome-wide analysis of Stowaway-like MITEs in wheat reveals high sequence conservation, gene association, and genomic diversification.Plant physiology · 2013Article
- Exploring the diploid wheat ancestral A genome through sequence comparison at the high-molecular-weight glutenin locus region.Molecular genetics and genomics : MGG · 2012Article
- Marker utility of miniature inverted-repeat transposable elements for wheat biodiversity and evolution.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Article
- Ancient diversity of splicing motifs and protein surfaces in the wild emmer wheat (Triticum dicoccoides) LR10 coiled coil (CC) and leucine-rich repeat (LRR) domains.Molecular plant pathology · 2012Article
- Duplication and partitioning in evolution and function of homoeologous Q loci governing domestication characters in polyploid wheat.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The impact of Ty3-gypsy group LTR retrotransposons Fatima on B-genome specificity of polyploid wheats.BMC plant biology · 2011Article
- Mechanisms of haplotype divergence at the RGA08 nucleotide-binding leucine-rich repeat gene locus in wild banana (Musa balbisiana).BMC plant biology · 2010Article
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Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant genomes, in particular grass genomes, evolve very rapidly. The closely related A genomes of diploid, tetraploid, and hexaploid wheat are derived from a common ancestor that lived <3 million years ago and represent a good model to study molecular mechanisms involved in such rapid evolution. We have sequenced and compared physical contigs at the Lr10 locus on chromosome 1AS from diploid (211 kb), tetraploid (187 kb), and hexaploid wheat (154 kb). A maximum of 33% of the sequences were conserved between two species. The sequences from diploid and tetraploid wheat shared all of the genes, including Lr10 and RGA2 and define a first haplotype (H1). The 130-kb intergenic region between Lr10 and RGA2 was conserved in size despite its activity as a hot spot for transposon insertion, which resulted in >70% of sequence divergence. The hexaploid wheat sequence lacks both Lr10 and RGA2 genes and defines a second haplotype, H2, which originated from ancient and extensive rearrangements. These rearrangements included insertions of retroelements and transposons deletions, as well as unequal recombination within elements. Gene disruption in haplotype H2 was caused by a deletion and subsequent large inversion. Gene conservation between H1 haplotypes, as well as conservation of rearrangements at the origin of the H2 haplotype at three different ploidy levels indicate that the two haplotypes are ancient and had a stable gene content during evolution, whereas the intergenic regions evolved rapidly. Polyploidization during wheat evolution had no detectable consequences on the structure and evolution of the two haplotypes.
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