ReviewJournal of neurovirology2005
The role of immune responses in the pathogenesis of rabies.
Review in Journal of neurovirology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- A One Medicine Mission for an Effective Rabies Therapy.Frontiers in veterinary science · 2022Article
- Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection.Revista do Instituto de Medicina Tropical de Sao Paulo · 2021Article
- Article
- Phosphoprotein Gene of Wild-Type Rabies Virus Plays a Role in Limiting Viral Pathogenicity and Lowering the Enhancement of BBB Permeability.Frontiers in microbiology · 2020Article
- Natural Infection with Rabies Virus: A Histopathological and Immunohistochemical Study of Human Brains.Osong public health and research perspectives · 2019Article
- Article
- The production of antibody by invading B cells is required for the clearance of rabies virus from the central nervous system.PLoS neglected tropical diseases · 2009Article
- Feline rabies. ABCD guidelines on prevention and management.Journal of feline medicine and surgery · 2009Review
- Detection of cellular immunity to rabies antigens in human vaccinees.Journal of clinical immunology · 2006Article
- Rabies.Current neurology and neuroscience reports · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
In the absence of treatment, infection with a variety of rabies virus strains most often results in a lethal outcome. This can be averted by prompt immunization following exposure demonstrating that the development of anti-rabies viral immunity prior to extensive infection of neurons is protective. Otherwise it might be expected that immune clearance of the virus would result in neurological sequelae. Thus, the capacity of a rabies virus to induce a protective immune response is a major, negative determinant of its pathogenicity and highly pathogenic rabies viruses have characteristics that avoid triggering protective immune responses. On the other hand, there is evidence that certain aspects of immunity may contribute to the pathogenesis of rabies under certain circumstances. The relationship between rabies virus and the immune system of the host is the focus of this review.
Indexed as
Identifiers
15804966What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.