ArticleJournal of neurovirology2005
A case of a progressive multifocal leukoencephalopathy patient with four different JC virus transcriptional control region rearrangements in cerebrospinal fluid, blood, serum, and urine.
Article in Journal of neurovirology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Genetic Diversity of the Polyomavirus JC and Implications for the Pathogenesis of Progressive Multifocal Leukoencephalopathy.Viruses · 2026Review
- Complete Response to Nivolumab in Recurrent/Metastatic HPV-Positive Head and Neck Squamous Cell Carcinoma Patient After Progressive Multifocal Leukoencephalopathy: A Case Report.Frontiers in oncology · 2021Article
- COS-7 cells are a cellular model to monitor polyomavirus JC miR-J1-5p expression.Molecular biology reports · 2020Article
- Human Polyomaviruses in the Cerebrospinal Fluid of Neurological Patients.Microorganisms · 2019Article
- [Progress on pathogenesis of progressive multifocal leukoence-phalopathy].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2018Review
- Detection and analysis of variants of JC polyomavirus in urine samples from HIV-1-infected patients in China's Zhejiang Province.The Journal of international medical research · 2018Article
- Exploring the role of NCCR variation on JC polyomavirus expression from dual reporter minicircles.PloS one · 2018Article
- JC virus infection is acquired very early in life: evidence from a longitudinal serological study.Journal of neurovirology · 2017Article
- JC virus urinary excretion and seroprevalence in natalizumab-treated multiple sclerosis patients.Journal of neurovirology · 2015Article
- Evidence supporting the association of polyomavirus BK genome with prostate cancer.Medical microbiology and immunology · 2013Article
- New insights on human polyomavirus JC and pathogenesis of progressive multifocal leukoencephalopathy.Clinical & developmental immunology · 2013Review
- JC virus detection and JC virus-specific immunity in natalizumab-treated multiple sclerosis patients.Journal of translational medicine · 2012Article
- Specific protein profile in cerebrospinal fluid from HIV-1-positive cART-treated patients affected by neurological disorders.Journal of neurovirology · 2012Article
- JC virus load in cerebrospinal fluid and transcriptional control region rearrangements may predict the clinical course of progressive multifocal leukoencephalopathy.Journal of cellular physiology · 2012Article
- JC virus promoter/enhancers contain TATA box-associated Spi-B-binding sites that support early viral gene expression in primary astrocytes.The Journal of general virology · 2012Article
- Pathogenesis of progressive multifocal leukoencephalopathy--revisited.The Journal of infectious diseases · 2011Review
- Rearranged JC virus noncoding control regions found in progressive multifocal leukoencephalopathy patient samples increase virus early gene expression and replication rate.Journal of virology · 2010Article
- Lymphotropic polyomavirus is detected in peripheral blood from immunocompromised and healthy subjects.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2010Article
- Investigation of pre-diagnostic virological markers for progressive multifocal leukoencephalopathy in human immunodeficiency virus-infected patients.Journal of medical virology · 2009Article
- JC virus VP1 loop-specific polymorphisms are associated with favorable prognosis for progressive multifocal leukoencephalopathy.Journal of neurovirology · 2009Article
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Authors and funding
9 authors.
Funding
Abstract
JC virus (JCV) is the etiological agent of progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease of the central nervous system (CNS). During the acquired immunodeficiency syndrome (AIDS) epidemic, it was the cause of the death in up to 8% of AIDS patients. The genomic organization of JCV and, in particular, the hypervariability of the transcriptional control region (TCR), a regulatory noncoding region, are well known. Given that the TCR plays a central role in the viral replication of JCV, a crucial role in the determination of the neurotropism and in the pathogenic capabilities of the virus is also suspected. Here the authors describe a case of PML that did not respond to highly active antiretroviral therapy (HAART) therapy. There was a simultaneous presence of JCV strains with four different TCR structures in urine, peripheral blood cells, serum, and cerebrospinal fluid (CSF) samples. These data confirmed that the presence of the archetype TCt is restricted to urine, while also suggesting that the degree of the rearrangement varies and increases from the peripheral blood to CSF.
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