Evidence map›Paper›PMID 15804958›Full record

ArticleJournal of neurovirology2005

Atypical radiological presentation of progressive multifocal leukoencephalopathy following liver transplantation.

Marco A Lima, Douglas W Hanto, Michael P Curry, Michael T Wong, Xin Dang, Igor J Koralnik

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Journal of neurovirology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Progressive Multifocal Leukoencephalopathy after Three Consecutive Liver Transplantations.International journal of organ transplantation medicine · 2015
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Marco A LimaDepartment of Neurology, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Douglas W Hanto
Michael P Curry
Michael T Wong
Xin Dang
Igor J Koralnik
Beth Israel Deaconess Medical Center · USUniversidade Federal do Rio de Janeiro · BR

Funding

Role of Inflammation in Progressive Multifocal LeukoencephalopathyR01NS047029 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI KORALNIK, IGOR J. · 2004 to 2018
$6.4M
CELLULAR IMMUNITY TO JC VIRUS IN AIDS ASSOCIATED PMLR01NS041198 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KORALNIK, IGOR J. · 2001 to 2009
$3.3M
NINDS NIH HHS NS 047029NINDS NIH HHS R01 NS/AI 41198
6 · The paper itself

Abstract

Progressive multifocal leukoencephalopathy (PML), a demyelinating disease of the brain caused by JC virus (JCV), occurs following transplantation and other conditions associated with immunosuppression. On magnetic resonance imaging (MRI), PML lesions typically appear as hyperintense signal on T2-weighted and FLAIR images located in the subcortical white matter, which are devoid of contrast enhancement or mass effect. The prognosis is poor, but unusual inflammatory forms of PML characterized by contrast enhancement have been associated with a cellular immune response against JCV and a better prognosis. The authors report an atypical presentation of PML with contrast-enhancing lesions and mass effect on the MRI in a liver transplant recipient,who had a progressive course and fatal outcome.

Indexed as

Liver TransplantationAdultBrainDiagnosis, DifferentialFemaleHumansImmunocompromised HostJC VirusLeukoencephalopathy, Progressive MultifocalPrognosisRadiography

Identifiers

PMID15804958
OpenAlexW2062088157

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.