ReviewJournal of neurovirology2005
Autistic disorder and viral infections.
Review in Journal of neurovirology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03180112 (The Association Between Herpes Simplex Viruses), which is not on this map. Cited by 85 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Association Between Herpes Simplex Viruses (Type One and Two) and Autism Spectrum Disorders
Who cites it
85 citing papers in PubMed, 1 synthesis or guideline pooled it, 248 citations in OpenAlex.
- Association between human herpesviruses infections and childhood neurodevelopmental disorders: insights from two-sample mendelian randomization analyses and systematic review with meta-analysis.Italian journal of pediatrics · 2024Pooled it
- Risperidone dosing in children and adolescents with autistic disorder: a double-blind, placebo-controlled study.Journal of autism and developmental disorders · 2013Trial
- Associations between chronic placental inflammation, fetal brain development and later autism traits.Brain, behavior, & immunity - health · 2026Article
- Prenatal chronic inflammation and children's executive function development.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2025Article
- Prenatal exposure to valproic acid reduces synaptic δ-catenin levels and disrupts ultrasonic vocalization in neonates.Neuropharmacology · 2024Article
- Microbes and Mental Illness: Past, Present, and Future.Healthcare (Basel, Switzerland) · 2023Review
- Viruses and autism: A Bi-mutual cause and effect.World journal of virology · 2023Review
- Mouse maternal odontogenic infection withFrontiers in pediatrics · 2023Article
- Cannabidiol for the treatment of autism spectrum disorder: hope or hype?Psychopharmacology · 2022Review
- Possible Effect of the use of Mesenchymal Stromal Cells in the Treatment of Autism Spectrum Disorders: A Review.Frontiers in cell and developmental biology · 2022Review
- Sex Differences in Autism Spectrum Disorder: Diagnostic, Neurobiological, and Behavioral Features.Frontiers in psychiatry · 2022Review
- SARS-CoV-2-associated cytokine storm during pregnancy as a possible risk factor for neuropsychiatric disorder development in post-pandemic infants.Neuropharmacology · 2021Review
- Astroglial Hemichannels and Pannexons: The Hidden Link between Maternal Inflammation and Neurological Disorders.International journal of molecular sciences · 2021Review
- Contribution of Pro-Inflammatory Molecules Induced by Respiratory Virus Infections to Neurological Disorders.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Association between Viral Infections and Risk of Autistic Disorder: An Overview.International journal of environmental research and public health · 2021Review
- A k-mer based approach for classifying viruses without taxonomy identifies viral associations in human autism and plant microbiomes.Computational and structural biotechnology journal · 2021Article
- New concepts in the development of schizophrenia, autism spectrum disorders, and degenerative brain diseases based on chronic inflammation: A working hypothesis from continued advances in neuroscience research.Surgical neurology international · 2021Review
- A Unifying Theory for Autism: The Pathogenetic Triad as a Theoretical Framework.Frontiers in psychiatry · 2021Article
- Critical Role of the Maternal Immune System in the Pathogenesis of Autism Spectrum Disorder.Biomedicines · 2020Review
- Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Autistic disorder (autism) is a behaviorally defined developmental disorder with a wide range of behaviors. Although the etiology of autism is unknown, data suggest that autism results from multiple etiologies with both genetic and environmental contributions, which may explain the spectrum of behaviors seen in this disorder. One proposed etiology for autism is viral infection very early in development. The mechanism, by which viral infection may lead to autism, be it through direct infection of the central nervous system (CNS), through infection elsewhere in the body acting as a trigger for disease in the CNS, through alteration of the immune response of the mother or offspring, or through a combination of these, is not yet known. Animal models in which early viral infection results in behavioral changes later in life include the influenza virus model in pregnant mice and the Borna disease virus model in newborn Lewis rats. Many studies over the years have presented evidence both for and against the association of autism with various viral infections. The best association to date has been made between congenital rubella and autism; however, members of the herpes virus family may also have a role in autism. Recently, controversy has arisen as to the involvement of measles virus and/or the measles, mumps, rubella (MMR) vaccine in the development of autism. Biological assays lend support to the association between measles virus or MMR and autism whereas epidemiologic studies show no association between MMR and autism. Further research is needed to clarify both the mechanisms whereby viral infection early in development may lead to autism and the possible involvement of the MMR vaccine in the development of autism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.