Evidence map›Paper›PMID 15802951›Full record

ReviewViral immunology2005

Identification of structural domains involved in astrovirus capsid biology.

Neel K Krishna

Open access · greenAbstract readComparative StudyReview
In one paragraph

Review in Viral immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 95 citations in OpenAlex.

  1. Porcine astrovirus: a review.Archives of virology · 2026
    Review
  2. Discovery of the order 'Virus evolution · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Screening and identification of protein interacting with goose astrovirus.Frontiers in cellular and infection microbiology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
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  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Neel K KrishnaDepartment of Pediatrics and the Center for Pediatric Research, Norfolk, VA 23510, USA. krishnnk@chkd.org
Children's Hospital of The King's Daughters · US

Funding

Molecular analysis of astrovirus capsid assemblyR21AI060874 · NIAID · EASTERN VIRGINIA MEDICAL SCHOOL · PI KRISHNA, NEEL KUMAR · 2004 to 2005
$381k
NIAID NIH HHS AI 608734NIAID NIH HHS R21 AI060874NIAID NIH HHS R21 AI060874-01
6 · The paper itself

Abstract

Coat proteins of non-enveloped, icosahedral viruses must perform a variety of functions during their life cycle such as assembly of the coat protein subunits into a closed shell, specific encapsidation of the viral nucleic acid, maturation of the capsid, interaction with host receptors, and disassembly to deliver the genetic information into the newly infected cell. A thorough understanding of the multiple capsid properties at the molecular level is required in order to identify potential targets for antiviral therapy and the prevention of viral disease. The system we have chosen for study is the astrovirus, a family of icosahedral, single-stranded RNA viruses that cause disease in mammals and birds. Very little is known about what regions of the coat protein contribute to the diverse capsid functions. This review will present novel structural predictions for the coat protein sequence of different astrovirus family members. Based on these predictions, we hypothesize that the assembly and RNA packaging functions of the astrovirus coat protein constitutes an individual domain distinct from the determinants required for receptor binding and internalization. Information derived from these structural predictions will serve as an important tool in designing experiments to understand astrovirus biology.

Indexed as

CapsidCapsid ProteinsMamastrovirusProtein Structure, TertiaryReceptors, VirusSequence Homology, Nucleic AcidVirus AssemblyCapsid ProteinsReceptors, Virus

Identifiers

PMID15802951
PMCPMC1393289
OpenAlexW2014270281

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.