ArticleGenetics2005
A high-frequency null mutant of an odorant-binding protein gene, Obp57e, in Drosophila melanogaster.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Adaptive Evolution of Odorant-Binding and Chemosensory Protein Gene Families in GenusBiomolecules · 2026Article
- Article
- Cuticular Hydrocarbon Content that Affects Male Mate Preference of Drosophila melanogaster from West Africa.International journal of evolutionary biology · 2012Article
- Making scents of behavioural genetics: lessons from Drosophila.Genetics research · 2010Review
- Natural variation in odorant recognition among odorant-binding proteins in Drosophila melanogaster.Genetics · 2010Article
- Genetic changes accompanying the evolution of host specialization in Drosophila sechellia.Genetics · 2009Article
- Rapid evolution of two odorant-binding protein genes, Obp57d and Obp57e, in the Drosophila melanogaster species group.Genetics · 2008Article
- Association of polymorphisms in odorant-binding protein genes with variation in olfactory response to benzaldehyde in Drosophila.Genetics · 2007Article
- Odorant-binding proteins OBP57d and OBP57e affect taste perception and host-plant preference in Drosophila sechellia.PLoS biology · 2007Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have found a null mutant of an odorant-binding protein, Obp57e, in Drosophila melanogaster. This frameshift mutation, which is a 10-bp deletion in the coding region, is at a high frequency in the Kyoto population and is also present in Taiwan and Africa. We have sequenced a 1.5-kb region including the tandemly duplicated gene, Obp57d, from 16 inbred lines sampled in Kyoto, Japan. The analyses showed a peak of nucleotide diversity and strong linkage disequilibrium around this mutation. This pattern suggests an elevated mutation rate or an influence of balancing selection in this region. The level of nucleotide divergence between D. melanogaster and D. simulans does not support the former possibility. Thus, this presence/absence polymorphism may be due to balancing selection, which takes advantage of the relatively weak functional constraint in members of a large gene family. In addition, the Obp57d gene region showed an excess of high-frequency-derived mutants that is consistent with a pattern predicted under positive natural selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.