ArticleGenetics2005
A genomics approach to the detection of positive selection in cattle: adaptive evolution of the T-cell and natural killer cell-surface protein CD2.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Divergent evolution and purifying selection of the Type 2 diabetes gene sequences in Drosophila: a phylogenomic study.Genetica · 2020Article
- Less is more: an adaptive branch-site random effects model for efficient detection of episodic diversifying selection.Molecular biology and evolution · 2015Article
- Classic selective sweeps revealed by massive sequencing in cattle.PLoS genetics · 2014Article
- Identification of recently selected mutations driven by artificial selection in hanwoo (korean cattle).Asian-Australasian journal of animal sciences · 2013Article
- A random effects branch-site model for detecting episodic diversifying selection.Molecular biology and evolution · 2011Article
- Article
- The bovine lactation genome: insights into the evolution of mammalian milk.Genome biology · 2009Article
- Detecting the effects of selection at the population level in six bovine immune genes.BMC genetics · 2008Article
- Protein coding gene nucleotide substitution pattern in the apicomplexan protozoa Cryptosporidium parvum and Cryptosporidium hominis.Comparative and functional genomics · 2008Article
- Article
- Article
- Linkage mapping of the locus for inherited ovine arthrogryposis (IOA) to sheep chromosome 5.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Genomic divergences among cattle, dog and human estimated from large-scale alignments of genomic sequences.BMC genomics · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The detection of adaptive evolution at the molecular level is of interest not only as an insight into the process of evolution but also because of its functional implications for genes of interest. Here, we present the first genomics approach to detecting positive selection operating on the Bos taurus lineage, an important domestic species. This analysis led to the identification of the T-cell and natural killer (NK) cell receptor cluster of differentiation 2 (CD2) as having a strong signal of selection. Further detailed investigation of CD2 revealed that this gene was subject to positive selection during the evolution of a number of mammalian lineages. Moreover, we show that selection has operated primarily on the extracellular domain of CD2 and discuss the implications of this for an important regulator of the adaptive immune response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.