Trial reportThe Journal of physiology2005
Preserved contribution of nitric oxide to baseline vascular tone in deconditioned human skeletal muscle.
Trial report in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01398943 (Regulation of Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Regulation of Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease: A Mechanistic Approach
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Single-leg disuse decreases skeletal muscle strength, size, and power in uninjured adults: A systematic review and meta-analysis.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Short-term unilateral leg immobilization alters peripheral but not central arterial structure and function in healthy young humans.European journal of applied physiology · 2011Trial
- Effects of acute nitric oxide synthase inhibition on lower leg vascular function in chronic tetraplegia.The journal of spinal cord medicine · 2009Trial
- Optimizing the predictive validity of NIRS kinetic profiles to predict aerobic capacity from a resting skeletal muscle occlusion test.Experimental physiology · 2026Article
- Validation of muscle oxygenation kinetics to predict aerobic fitness and exercise transition thresholds.Experimental physiology · 2026Article
- Vascular and Microvascular Dysfunction Induced by Microgravity and Its Analogs in Humans: Mechanisms and Countermeasures.Frontiers in physiology · 2020Review
- Higher oxidative stress in skeletal muscle of McArdle disease patients.Molecular genetics and metabolism reports · 2017Article
- The Effect of Nitric Oxide Inhibition in Spinal Cord Injured Humans with and without Preserved Sympathetic Control of the Vasculature.Frontiers in neuroscience · 2016Article
- Hindlimb unweighting does not alter vasoconstrictor responsiveness and nitric oxide-mediated inhibition of sympathetic vasoconstriction.The Journal of physiology · 2015Article
- Effect of unilateral forearm inactivity on endothelium-dependent vasodilator function in humans.European journal of applied physiology · 2013Article
- Unilateral lower limb suspension: integrative physiological knowledge from the past 20 years (1991-2011).European journal of applied physiology · 2012Review
- Low-volume strength and endurance training prevent the decrease in exercise hyperemia induced by non-dominant forearm immobilization.European journal of applied physiology · 2010Article
- Impact of inactivity and exercise on the vasculature in humans.European journal of applied physiology · 2010Review
- Flow-mediated dilatation in the superficial femoral artery is nitric oxide mediated in humans.The Journal of physiology · 2008Article
- Physical (in)activity and endothelium-derived constricting factors: overlooked adaptations.The Journal of physiology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deconditioning is a risk factor for cardiovascular disease. Exercise reduces this risk, possibly by improving the vascular endothelial nitric oxide (NO) pathway. The effect of deconditioning on the NO pathway is largely unknown. This study was designed to assess baseline NO availability in the leg vascular bed after extreme, long-term deconditioning (spinal cord-injured individuals, SCI) as well as after moderate, short-term deconditioning (4 weeks of unilateral lower limb suspension, ULLS). For this purpose, seven SCI were compared with seven matched controls. Additionally, seven healthy subjects were studied pre- and post-ULLS. Leg blood flow was measured by venous occlusion plethysmography at baseline and during infusion of 5 incremental dosages of N(G)-monomethyl-L-arginine (L-NMMA) into the femoral artery. Sodium nitroprusside (SNP) was infused to test vascular responsiveness to NO. Baseline leg vascular resistance tended to be higher in SCI compared with controls (37+/-4 versus 31+/-2 arbitrary units (AU), P=0.06). Deconditioning altered neither the vasoconstrictor response to L-NMMA (increase in resistance in SCI versus controls: 102+/-33% versus 69+/-9%; pre- versus post-ULLS: 95+/-18% versus 119+/-15%), nor the vascular responsiveness to NO. In conclusion, two human in vivo models of deconditioning show a preserved baseline NO availability in the leg skeletal muscle vascular bed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.