ArticleAmerican journal of human genetics2005
Quantitative founder-effect analysis of French Canadian families identifies specific loci contributing to metabolic phenotypes of hypertension.
Article in American journal of human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- The epithelial sodium channel γ-subunit gene and blood pressure: family based association, renal gene expression, and physiological analyses.Hypertension (Dallas, Tex. : 1979) · 2011Pooled it
- Genome-wide linkage and positional candidate gene study of blood pressure response to dietary potassium intervention: the genetic epidemiology network of salt sensitivity study.Circulation. Cardiovascular genetics · 2010Trial
- OBESITY & HYPERTENSION - 'TWO PEAS IN A POD'.Annals of Ibadan postgraduate medicine · 2024Article
- Parental overnutrition by carbohydrates in developmental origins of metabolic syndrome.Physiological research · 2021Review
- SARS-CoV-2 Receptor ACE2 Gene Is Associated with Hypertension and Severity of COVID 19: Interaction with Sex, Obesity, and Smoking.American journal of hypertension · 2021Article
- Dynamic genetic linkage of intermediate blood pressure phenotypes during postural adaptations in a founder population.Physiological genomics · 2013Article
- Interactions between the FTO and GNB3 genes contribute to varied clinical phenotypes in hypertension.PloS one · 2013Article
- Molecular genetics of the psychosis phenotype.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2012Review
- Genetic mapping of habitual substance use, obesity-related traits, responses to mental and physical stress, and heart rate and blood pressure measurements reveals shared genes that are overrepresented in the neural synapse.Hypertension research : official journal of the Japanese Society of Hypertension · 2012Article
- Between candidate genes and whole genomes: time for alternative approaches in blood pressure genetics.Current hypertension reports · 2012Review
- Central role of guanylyl cyclase in natriuretic peptide signaling in hypertension and metabolic syndrome.Molecular and cellular biochemistry · 2010Review
- Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice.The Journal of clinical investigation · 2009Article
- Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences.Physiological genomics · 2009Article
- The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia.Schizophrenia bulletin · 2008Article
- Intergenerational and Genealogical Approaches for the Study of Longevity in the Saguenay-Lac-St-Jean Population.Human nature (Hawthorne, N.Y.) · 2008Article
- A whole genome linkage scan for QTLs underlying peak bone mineral density.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008Article
- Article
- A locus on chromosome 10 influences C-reactive protein levels in two independent populations.Human genetics · 2007Article
- A comprehensive view of sex-specific issues related to cardiovascular disease.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2007Review
- Heritability of cardiovascular and personality traits in 6,148 Sardinians.PLoS genetics · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 9 institutions in 3 countries.
Funding
Abstract
The Saguenay-Lac St-Jean population of Quebec is relatively isolated and has genealogical records dating to the 17th-century French founders. In 120 extended families with at least one sib pair affected with early-onset hypertension and/or dyslipidemia, we analyzed the genetic determinants of hypertension and related cardiovascular and metabolic conditions. Variance-components linkage analysis revealed 46 loci after 100,000 permutations. The most prominent clusters of overlapping quantitative-trait loci were on chromosomes 1 and 3, a finding supported by principal-components and bivariate analyses. These genetic determinants were further tested by classifying families by use of LOD score density analysis for each measured phenotype at every 5 cM. Our study showed the founder effect over several generations and classes of living individuals. This quantitative genealogical approach supports the notion of the ancestral causality of traits uniquely present and inherited in distinct family classes. With the founder effect, traits determined within population subsets are measurably and quantitatively transmitted through generational lineage, with a precise component contributing to phenotypic variance. These methods should accelerate the uncovering of causal haplotypes in complex diseases such as hypertension and metabolic syndrome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.