ArticlePathology oncology research : POR2005
Changes of cell adhesion and extracellular matrix (ECM) components in cervical intraepithelial neoplasia.
Article in Pathology oncology research : POR, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Prostaglandin-induced cervical remodelling in humans in the first trimester is associated with increased expression of specific tight junction, but not gap junction proteins.Journal of translational medicine · 2012Trial
- Differential Impact of Membrane-Bound and Soluble Forms of the Prognostic Marker Syndecan-1 on the Invasiveness, Migration, Apoptosis, and Proliferation of Cervical Cancer Cells.Frontiers in oncology · 2022Article
- E7 oncoprotein from human papillomavirus 16 alters claudins expression and the sealing of epithelial tight junctions.International journal of oncology · 2020Article
- Aberrant Expression of Syndecan-1 in Cervical Cancers.Pathology oncology research : POR · 2020Article
- Global targetome analysis reveals critical role of miR-29a in pancreatic stellate cell mediated regulation of PDAC tumor microenvironment.BMC cancer · 2020Article
- Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseases.Clinics (Sao Paulo, Brazil) · 2018Review
- CLDN1 expression in cervical cancer cells is related to tumor invasion and metastasis.Oncotarget · 2016Article
- 3D texture analysis for classification of second harmonic generation images of human ovarian cancer.Scientific reports · 2016Article
- Claudin 1 expression characterizes human uterine cervical reserve cells.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2013Article
- The claudin family of proteins in human malignancy: a clinical perspective.Cancer management and research · 2013Review
- Claudins overexpression in ovarian cancer: potential targets for Clostridium Perfringens Enterotoxin (CPE) based diagnosis and therapy.International journal of molecular sciences · 2013Review
- Matrix metalloproteinase-9 is a prognostic marker for patients with cervical cancer.Medical oncology (Northwood, London, England) · 2012Article
- Claudins 1, 3M, 3S, 4, 5 and 7 in vulvar neoplasms compared with vulvar squamous cell carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Structure and function of intercellular junctions in human cervical and vaginal mucosal epithelia.Biology of reproduction · 2011Article
- Claudin expression in pancreatic endocrine tumors as compared with ductal adenocarcinomas.Virchows Archiv : an international journal of pathology · 2007Article
- The Effect of Commonly Used Excipients on the Epithelial Integrity of Human Cervicovaginal Tissue.AIDS research and human retrovirusesArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell-cell and cell-extracellular matrix interaction is crucial in tumor progression. Tight junction (TJ) proteins as occludin and claudins (CLDNs) play important role in this process together with several extracellular matrix components, as syndecan. Our previous work suggested significant changes in the expression of claudins even in the early stages of cervical carcinogenesis. The aim of our present work was to study the expression of occludin and syndecan-1, as compared to CLDNs, in early phases of cervical carcinogenesis. Paraffin sections of 50 samples were studied by immunohistochemistry, including cervical intraepithelial neoplasias (CINI-II-III), in situ carcinomas (CIS) and normal cervical samples. Occludin and CLDN-2 were found colocalized in the basal layer, while syndecan-1 and CLDN-1, -4 and -7 were coexpressed in the parabasal and intermedier layers in normal epithelia. Intensity of occludin staining decreased in CIN/CIS lesions, although it was more extended towards the upper epithelial layers with inverse relation with grades, as seen in the case of CLDN-2 expression. CLDN-1, -2, -4 and -7 were detected in the entire epithelium in CIN, showing decrease in CIS. The progression of CIN was associated with reduced syndecan-1 expression, in contrast to CLDN-1, -4 and -7 which increased toward CIS. The obtained data suggest that significant changes occur in the composition of cell adhesion complexes even in early stages of cervical carcinogenesis. The pattern of expression is characteristic for the alteration, the changes in the different components, however, are not parallel with each other.
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