ArticleLeukemia2005
ZAP-70 is expressed by a subset of normal human B-lymphocytes displaying an activated phenotype.
Article in Leukemia, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 86 citations in OpenAlex.
- Identification and Functional Investigation of Hub Genes Associated with Follicular Lymphoma.Biochemical genetics · 2025Article
- Profiling of human lymphocytes reveals a specific network of protein kinases modulated by endurance training status.Scientific reports · 2020Article
- ZAP-70 Shapes the Immune Microenvironment in B Cell Malignancies.Frontiers in oncology · 2020Review
- Beyond TCR Signaling: Emerging Functions of Lck in Cancer and Immunotherapy.International journal of molecular sciences · 2019Review
- Targeting B cell receptor signalling in cancer: preclinical and clinical advances.Nature reviews. Cancer · 2018Review
- Chronic Lymphocytic Leukemia B-Cell Normal Cellular Counterpart: Clues From a Functional Perspective.Frontiers in immunology · 2018Review
- SLP76 integrates into the B-cell receptor signaling cascade in chronic lymphocytic leukemia cells and is associated with an aggressive disease course.Haematologica · 2016Article
- Gefitinib targets ZAP-70-expressing chronic lymphocytic leukemia cells and inhibits B-cell receptor signaling.Cell death & disease · 2014Article
- B cell receptor signaling in chronic lymphocytic leukemia.Trends in immunology · 2013Review
- Article
- Detection methods of ZAP-70 in chronic lymphocytic leukemia.Clinical and experimental medicine · 2012Review
- Article
- Management of patients with chronic lymphocytic leukemia with a high risk of adverse outcome: the Mayo Clinic approach.Leukemia & lymphoma · 2011Review
- Review
- Chronic lymphocytic leukaemia: a disease of activated monoclonal B cells.Best practice & research. Clinical haematology · 2010Review
- Article
- Chronic lymphocytic leukemia: biology and current treatment.Current oncology reports · 2007Review
- The role of prognostic factors in assessing 'high-risk' subgroups of patients with chronic lymphocytic leukemia.Leukemia · 2007Review
- B cell chronic lymphocytic leukaemia/small lymphocytic lymphoma: role of ZAP70 determination on bone marrow biopsy specimens.Journal of clinical pathology · 2007Article
- Prognostic factors in chronic lymphocytic leukemia.Current hematologic malignancy reports · 2007Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The Syk family tyrosine kinase ZAP-70 is essential for normal T-cell development and signaling. Recently, leukemic cells from some patients with B-cell chronic lymphocytic leukemia (B-CLL) were shown to express ZAP-70. Owing to the prognostic value of B-CLL ZAP-70 expression, this phenotype may reflect intrinsic biological differences between the two subsets of disease. However, it remains unclear whether CLL-B cells aberrantly acquire ZAP-70 expression during the transformation process or whether ZAP-70 may be expressed under certain conditions in normal human B-lymphocytes. To discriminate between these two possibilities, we assessed ZAP-70 expression in normal human B-lymphocytes. Our data demonstrate that ZAP-70 is expressed in a subpopulation of tonsillar and splenic normal B-lymphocytes that express an activated phenotype. Furthermore, ZAP-70 expression can be induced in vitro upon stimulation of blood and tonsillar B cells. Finally, we show that phosphorylation of ZAP-70 occurs in tonsillar B cells with stimulation through the B-cell receptor. These results provide new insight into normal human B-cell biology as well as provide clues about the transformed cell in B-CLL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.