ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Development of a new genetic model for absence epilepsy: spike-wave seizures in C3H/He and backcross mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Midline thalamic neurons show early hypersynchrony during absence seizures in mouse models.iScience · 2026Article
- Combining residual U-Net and data augmentation for dense temporal segmentation of spike wave discharges in single-channel EEG.Scientific reports · 2026Article
- A mouse model of GRIN2D developmental and epileptic encephalopathy recapitulates the human disease.Brain : a journal of neurology · 2026Article
- Alternating hemiplegia of childhood associated mutations in Atp1a3 reveal diverse neurological alterations in mice.Neurobiology of disease · 2025Article
- A Role for δ Subunit-Containing GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neuronal rhythmicity and cortical arousal in a mouse model of absence epilepsy.Experimental neurology · 2024Article
- Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor.Frontiers in cellular neuroscience · 2023Article
- Sensory regulation of absence seizures in a mouse model ofiScience · 2022Article
- Modulation of pacemaker channel function in a model of thalamocortical hyperexcitability by demyelination and cytokines.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Genetic backgrounds have unique seizure response profiles and behavioral outcomes following convulsant administration.Epilepsy & behavior : E&B · 2019Article
- The effects of carbamazepine in the intrahippocampal kainate model of temporal lobe epilepsy depend on seizure definition and mouse strain.Epilepsia open · 2016Article
- Cellular and circuit models of increased resting-state network gamma activity in schizophrenia.Neuroscience · 2016Review
- SWDreader: a wavelet-based algorithm using spectral phase to characterize spike-wave morphological variation in genetic models of absence epilepsy.Journal of neuroscience methods · 2015Article
- Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer's disease mouse model.Alzheimer's research & therapy · 2015Article
- Ethosuximide reduces electrographical and behavioral correlates of alcohol withdrawal seizure in DBA/2J mice.Alcohol (Fayetteville, N.Y.) · 2014Article
- Unraveling genetic modifiers in the gria4 mouse model of absence epilepsy.PLoS genetics · 2014Article
- Scn8a voltage-gated sodium channel mutation alters seizure and anxiety responses to acute stress.Psychoneuroendocrinology · 2014Article
- Altered sleep regulation in a mouse model of SCN1A-derived genetic epilepsy with febrile seizures plus (GEFS+).Epilepsia · 2013Article
- Development of spike-wave seizures in C3H/HeJ mice.Epilepsy research · 2009Article
- Heterozygous mutations of the voltage-gated sodium channel SCN8A are associated with spike-wave discharges and absence epilepsy in mice.Human molecular genetics · 2009Article
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6 authors.
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Abstract
To characterize the genetic basis of spike-wave discharges (SWDs) detected by electroencephalography (EEG) in C3H/He mice, substrains of C3H mice were evaluated by EEG and sensitivity to ethosuximide. Crosses with the SWD-negative strain C57BL/6J were performed to map the underlying gene(s). C3H/He substrains exhibited a modest incidence (average of 19 SWDs per hour) of 7-8 Hz SWDs when at rest, compared with the C3HeB/Fe subline (four SWDs per hour). In the mapping backcross, however, many mice showed a very high incidence (50-220 SWDs per hour) throughout the recording period. SWDs were first detected at 3.5 weeks of age, were associated with behavioral arrest, were suppressed by ethosuximide, and were strongest in the cerebral cortex and thalamus. The major C3H determinant of SWDs, spkw1 (spike-wave 1), mapped to chromosome (Chr 9), and together with a C57BL/6J determinant on Chr 8, spkw2, accounted for more than one-half of the phenotypic variation in the backcross mice. The modest SWD incidence in C3H/He mice and the high incidence in backcrosses implies that SWD could be a confounding variable for other behaviors. Because C3H/He mice have no other brain abnormalities, they are an attractive alternative for studying idiopathic absence epilepsy.
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