ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Retinoic acid-induced chromatin remodeling of mouse kappa opioid receptor gene.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Epigenetic Regulation in Primary CNS Tumors: An Opportunity to Bridge Old and New WHO Classifications.Cancers · 2023Review
- Epigenetic Modulation of Opioid Receptors by Drugs of Abuse.International journal of molecular sciences · 2022Review
- Coordinated repressive chromatin-remodeling of Oct4 and Nanog genes in RA-induced differentiation of embryonic stem cells involves RIP140.Nucleic acids research · 2014Article
- Prefrontal cortical dysfunction after overexpression of histone deacetylase 1.Biological psychiatry · 2013Article
- Epigenetic determinants of healthy and diseased brain aging and cognition.JAMA neurology · 2013Review
- κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction.Trends in neurosciences · 2012Review
- Stress-induced epigenetic regulation of κ-opioid receptor gene involves transcription factor c-Myc.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Transcriptional and epigenetic regulation of opioid receptor genes: present and future.Annual review of pharmacology and toxicology · 2011Review
- Loss of pluripotency in human embryonic stem cells directly correlates with an increase in nuclear zinc.PloS one · 2010Article
- Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells.Molecular pharmacology · 2010Article
- Mu and kappa opioids modulate mouse embryonic stem cell-derived neural progenitor differentiation via MAP kinases.Journal of neurochemistry · 2010Article
- Distinct subcellular distribution of delta-opioid receptor fused with various tags in PC12 cells.Neurochemical research · 2008Article
- Article
- Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters.Molecular and cellular biology · 2007Article
- Axonal mRNA transport and localized translational regulation of kappa-opioid receptor in primary neurons of dorsal root ganglia.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Mu- and kappa-opioids induce the differentiation of embryonic stem cells to neural progenitors.The Journal of biological chemistry · 2006Article
- Netrin-1 signaling regulates de novo protein synthesis of kappa opioid receptor by facilitating polysomal partition of its mRNA.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Regulation of retinal dehydrogenases and retinoic acid synthesis by cholesterol metabolites.The EMBO journal · 2006Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The mouse kappa opioid receptor (KOR) gene is constitutively expressed in P19 embryonic stem cells but is first suppressed and reactivated during retinoic acid (RA)-induced neuronal differentiation. However, no RA response element (RARE) can be found in this gene regulatory region. The suppression and reactivation of the KOR gene in this neuronal differentiation model suggested chromatin remodeling occurred on this gene promoter triggered by RA induction. This study asks whether RA induces alteration in the nucleosomal structure of this gene promoter that has no apparent RARE and, if so, how RA remodels chromatin of this promoter. The results revealed two loose nucleosomes, N1 at -44 (3' boundary) from the transcription initiation site and N2 spanning the transcription initiation site, that are relevant to active transcription. RA formed a repressive chromatin configuration of this promoter by compacting nucleosome N1, followed by nucleosome N2 condensation. Chromatin immunoprecipitation assay demonstrated RA induced replacement of the c-Myc/Max complex with the Max/Mad1 complex on the E box located within nucleosome N1, coinciding with reduced Sp1 binding to GC boxes located within nucleosome N2 and recruitment of chromatin remodeling factor Brahma-related gene 1 (BRG-1) to this promoter. Consistently, histone deacetylation, Lys9 methylation, and hypophosphorylation of RNA polymerase II C-terminal domain were detected on this promoter after RA treatment. It is concluded that RA induces KOR gene suppression, as early neuronal differentiation marker, by inducing substitution of c-Myc/Max with Max/Mad on the E box and by BRG-1 involved nucleosome recruitment and chromatin condensation, thereby abolishing Sp1 binding.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.