ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Adherens junctions in myelinating Schwann cells stabilize Schmidt-Lanterman incisures via recruitment of p120 catenin to E-cadherin.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 78 citations in OpenAlex.
- Article
- Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions.Biology open · 2022Article
- Physiology of PNS axons relies on glycolytic metabolism in myelinating Schwann cells.PloS one · 2022Article
- Article
- Schwann cell interactions during the development of the peripheral nervous system.Developmental neurobiology · 2021Review
- Behind the pathology of macrophage-associated demyelination in inflammatory neuropathies: demyelinating Schwann cells.Cellular and molecular life sciences : CMLS · 2020Review
- Upregulation of large myelin protein zero leads to Charcot-Marie-Tooth disease-like neuropathy in mice.Communications biology · 2020Article
- LKB1 specifies neural crest cell fates through pyruvate-alanine cycling.Science advances · 2019Article
- Transcriptome analysis of adherens junction pathway-related genes after peripheral nerve injury.Neural regeneration research · 2018Article
- Wallerian demyelination: chronicle of a cellular cataclysm.Cellular and molecular life sciences : CMLS · 2017Review
- Article
- Myelinating Schwann Cell Polarity and Mechanically-Driven Myelin Sheath Elongation.Frontiers in cellular neuroscience · 2017Review
- Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP.PLoS genetics · 2016Article
- Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway.Nature communications · 2016Article
- Involvement of membrane skeletal molecules in the Schmidt-Lanterman incisure in Schwann cells.Medical molecular morphology · 2016Review
- Label-free imaging of Schwann cell myelination by third harmonic generation microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- PMP22 is critical for actin-mediated cellular functions and for establishing lipid rafts.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Article
- In vivo introduction of transgenes into mouse sciatic nerve cells in situ using viral vectors.Nature protocols · 2014Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Schwann cell myelin contains highly compacted layers of membrane as well as noncompacted regions with a visible cytoplasm. One of these cytoplasmic compartments is the Schmidt-Lanterman incisure, which spirals through the compacted layers and is believed to help sustain the growth and function of compact myelin. Incisures contain adherens junctions (AJs), the key components of which are E-cadherin, its cytoplasmic partners called catenins, and F-actin. To explore in vivo the role of cadherin and catenins in incisures, E-cadherin mutant proteins that completely replace endogenous cadherin have been delivered to the cells using adenovirus. When the introduced cadherin lacked its extracellular domain, association of p120 catenin (p120ctn) with the cadherin did not occur, and incisures disappeared. Remarkably, the additional replacement of two phosphorylatable tyrosines by phenylalanine in the cytoplasmic tail of the mutant cadherin restored both p120ctn binding and incisure architecture, indicating that p120ctn recruitment is critical for incisures maintenance and might be regulated by phosphorylations. In addition, the ability of the p120ctn/cadherin complex to support incisures was blocked by mutation of the Rho GTPase regulatory region of the p120ctn, and downregulation of Rac1 activity at the junction reversed this inhibition. Because Rho GTPases regulate the state of the actin filaments, these findings suggest that one role of p120ctn in incisures is to organize the cytoskeleton at the AJ. Finally, developmental studies of Schwann cells demonstrated that p120ctn recruitment from the cytoplasm to the AJ occurs before the appearance of Rac1 GTPase and F-actin at the junction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.