SynthesisSexually transmitted infections2005
A systematic review of the epidemiology and interaction of herpes simplex virus types 1 and 2.
Synthesis in Sexually transmitted infections, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
71 citing papers in PubMed, 152 citations in OpenAlex.
- Projected public health benefits of a hypothetical HSV-1 vaccine in the United States: A mathematical modeling analysis.Science advances · 2026Article
- Mathematical modeling of the population-level impact of hypothetical herpes simplex virus type 2 curative therapy.Communications medicine · 2026Article
- Valacyclovir Mitigates Amyloid Plaque Deposition, P-Tau Aggregation, and Neuroinflammation in Streptozotocin induced Alzheimer's Disease Rat Model.Molecular neurobiology · 2026Article
- Clinical features and outcomes of herpes simplex viral infections with co-infection in 100 children.Frontiers in pediatrics · 2026Article
- Review
- Increased risk of dementia associated with herpes simplex virus infections: Evidence from a retrospective cohort study using U.S. electronic health records.Journal of Alzheimer's disease : JAD · 2025Article
- Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1.Acta pharmacologica Sinica · 2023Article
- Reviewing the Potential Links between Viral Infections and TDP-43 Proteinopathies.International journal of molecular sciences · 2023Review
- The Cholesterol Transport Inhibitor U18666A Interferes with Pseudorabies Virus Infection.Viruses · 2022Article
- An mRNA vaccine to prevent genital herpes.Translational research : the journal of laboratory and clinical medicine · 2022Review
- Antiherpetic drugs: a potential way to prevent Alzheimer's disease?Alzheimer's research & therapy · 2022Article
- Superior antiviral activity of IFNβ in genital HSV-1 infection.Frontiers in cellular and infection microbiology · 2022Article
- Guinea Pig and Mouse Models for Genital Herpes Infection.Current protocols · 2021Article
- Speckles and paraspeckles coordinate to regulate HSV-1 genes transcription.Communications biology · 2021Article
- Synthesis and Biological Evaluation of Amidinourea Derivatives against Herpes Simplex Viruses.Molecules (Basel, Switzerland) · 2021Article
- Herpes simplex virus, early neuroimaging markers and incidence of Alzheimer's disease.Translational psychiatry · 2021Article
- Review
- Genital herpes as still significant dermatological, gynaecological and venereological problem.Postepy dermatologii i alergologii · 2021Review
- Vaccine Development for Herpes Simplex Viruses: A Commentary of Special Issue Editors.Vaccines · 2021Article
- Seroprevalence and characterisation of herpes simplex virus from human immunodeficiency virus in samples collected from two provinces in South Africa: a retrospective study.F1000Research · 2021Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo explore epidemiological evidence about the interaction of herpes simplex virus (HSV) 1 and HSV-2 infections.
methodsA systematic review was undertaken of published epidemiological studies describing the pattern of HSV-1 or HSV-2 by age, and the coincidence of the two viral infections.
resultsIn cross sectional studies the unadjusted odds of HSV-2 are greater in those with HSV-1 infection in study populations categorised as "low risk" (p = 0.06) and across European populations (p = 0.001). This was not evident in "high risk" populations or in the United States. This increased risk of HSV-2 in those with HSV-1 infection does not agree with the results of prospective studies where there is a non-significant trend towards a lower risk of HSV-2 infection associated with previous HSV-1 infection.
conclusions"Low risk" and European populations have a relatively low HSV-2 seroprevalence and infection is more concentrated in those with characteristics putting them at high risk for both HSV-1 and HSV-2. This confounding could mask any protective effect of HSV-1, which is hinted at, but not demonstrated, in prospective and adjusted studies.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.