Evidence map›Paper›PMID 15798462›Full record

ArticleAnnals of surgery2005

2003 report of the intestine transplant registry: a new era has dawned.

David Grant, Kareem Abu-Elmagd, Jorge Reyes, Andreas Tzakis, Alan Langnas, Thomas Fishbein, Olivier Goulet, Douglas Farmer, Intestine Transplant Registry

Abstract readComparative Study
In one paragraph

Article in Annals of surgery, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Organ allocation in pediatric abdominal transplant.Seminars in pediatric surgery · 2022
    Article
  9. Article
  10. Review
  11. R-Spondin 1 (RSPO1) Increases Mouse Intestinal Organoid Unit Size and SurvivalFrontiers in bioengineering and biotechnology · 2020
    Article
  12. Article
  13. Review
  14. Visceral transplantation in patients with intestinal-failure associated liver disease: Evolving indications, graft selection, and outcomes.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Intestinal transplantation in children: current status.Pediatric surgery international · 2016
    Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

David GrantUniversity Health Network, Toronto General Hospital, 200 Elizabeth Street, NCSB 11C-1248, Toronto, ON M5G 2C4, Canada. david.grant@uhn.on.ca
Kareem Abu-Elmagd
Jorge Reyes
Andreas Tzakis
Alan Langnas
Thomas Fishbein
Olivier Goulet
Douglas Farmer
Intestine Transplant Registry

Funding

Serum Citrulline in Rejection of Intestinal TransplantsR03DK061445 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI TZAKIS, ANDREAS GERASIMOS · 2004 to 2006
$299k
NIDDK NIH HHS 1 R03 DK61445-01A2NIDDK NIH HHS R03 DK061445
6 · The paper itself

Abstract

summary background dataThe intestine has been more difficult to transplant than other solid organs. We analyzed registry data to determine the scope and success of intestine transplantation in the current era.

methodsAll known intestinal-transplant programs participated. Patient- and graft-survival estimates were obtained using the Kaplan-Meier product limit method and were analyzed with the Wilcoxon statistic.

resultsSixty-one programs provided data on 989 grafts in 923 patients. Four patients were lost to follow-up. The short-gut syndrome was the most common primary indication for transplantation. Sixty-one percent of the recipients were < or =18 years. Proportionally more combined intestinal and liver transplants were performed in this group. More than 80% of all current survivors had stopped parenteral nutrition and resumed normal daily activities. A multivariate analysis of cases within the last 5 years revealed that transplantation of patients waiting at home, recipient age, antibody induction immune suppression, and center experience with at least 10 cases were associated with improved patient survival. One-year graft survival rates of 81% were achieved in patients who were induced with antithymocyte globulin and maintained on tacrolimus.

conclusionsTransplantation is an effective therapy for the treatment of patients with end-stage intestine failure who cannot tolerate parenteral nutrition. With newer immune suppressive protocols, 1-year graft and patient survival rates approach the results of liver transplantation. Further improvement in survival are expected with early referral since suitable donor organs are scarce and survival rates are better when patients are well enough to wait at home for their transplant.

Indexed as

AdultAge FactorsChildChild, PreschoolConfidence IntervalsFemaleGraft RejectionGraft SurvivalHumansIntestine, SmallLogistic ModelsMaleMiddle AgedProbabilityPrognosisProgram Evaluation

Identifiers

PMID15798462
PMCPMC1357064

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.