ArticleMolecular and cellular biology2005
Strong polyadenylation and weak pausing combine to cause efficient termination of transcription in the human Ggamma-globin gene.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- A combinatorial view of old and new RNA polymerase II modifications.Transcription · 2020Review
- Fetal γ-globin genes are regulated by theBlood · 2018Article
- WNK1 kinase and the termination factor PCF11 connect nuclear mRNA export with transcription.Genes & development · 2017Article
- KDM5 lysine demethylases are involved in maintenance of 3'UTR length.Science advances · 2016Article
- Getting up to speed with transcription elongation by RNA polymerase II.Nature reviews. Molecular cell biology · 2015Review
- Transcription termination and the control of the transcriptome: why, where and how to stop.Nature reviews. Molecular cell biology · 2015Review
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- AT-rich sequence elements promote nascent transcript cleavage leading to RNA polymerase II termination.Nucleic acids research · 2013Article
- Single-molecule studies of RNAPII elongation.Biochimica et biophysica acta · 2013Review
- Ending the message: poly(A) signals then and now.Genes & development · 2011Review
- Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination.Molecular cell · 2011Article
- Unravelling the means to an end: RNA polymerase II transcription termination.Nature reviews. Molecular cell biology · 2011Review
- POLYAR, a new computer program for prediction of poly(A) sites in human sequences.BMC genomics · 2010Article
- Transcription termination by nuclear RNA polymerases.Genes & development · 2009Article
- Molecular characterization of infectious clones of the minute virus of canines reveals unique features of bocaviruses.Journal of virology · 2009Article
- Intron delays and transcriptional timing during development.Developmental cell · 2008Review
- A systematic analysis of disease-associated variants in the 3' regulatory regions of human protein-coding genes I: general principles and overview.Human genetics · 2006Review
- Pause sites promote transcriptional termination of mammalian RNA polymerase II.Molecular and cellular biology · 2006Article
- Transcriptional termination sequences in the mouse serum albumin gene.RNA (New York, N.Y.) · 2006Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The human gamma-globin genes form part of a 5-kb tandem duplication within the beta-globin gene cluster on chromosome 11. Despite a high degree of identity between the two genes, we show that while the upstream Ggamma-globin gene terminates transcription efficiently, termination in the Agamma gene is inefficient. This is primarily due to the different strengths of the polyA signals of the two genes; Ggamma-globin has a functionally stronger polyA signal than the Agamma gene. The probable cause of this difference in polyA efficiency characteristics lies with a number of base changes which reduce the G/U content of the GU/U-rich region of the Agamma polyA signal relative to that of Ggamma. The 3' flanking regions of the two gamma-globin genes have similar abilities to promote transcription termination. We found no evidence to suggest a cotranscriptional cleavage event, such as that seen in the human beta-globin gene, occurs in either gamma-globin 3' flank. Instead we find evidence that the 3' flank of the Ggamma-globin gene contains multiple weak pause elements which, combined with the strong polyA signal the gene possesses, are likely to cause gradual termination across the 3' flank.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.