ArticleMolecular and cellular biology2005
The p53 tumor suppressor protein represses human snRNA gene transcription by RNA polymerases II and III independently of sequence-specific DNA binding.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
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- ATF3 promotes erastin-induced ferroptosis by suppressing system XcCell death and differentiation · 2020Article
- Linking Endoplasmic Reticular Stress and Alternative Splicing.International journal of molecular sciences · 2018Review
- Comprehensive molecular biomarker identification in breast cancer brain metastases.Journal of translational medicine · 2017Article
- PRC2 regulates RNA polymerase III transcribed non-translated RNA gene transcription through EZH2 and SUZ12 interaction with TFIIIC complex.Nucleic acids research · 2015Article
- Covalent small ubiquitin-like modifier (SUMO) modification of Maf1 protein controls RNA polymerase III-dependent transcription repression.The Journal of biological chemistry · 2013Article
- Requirement for SNAPC1 in transcriptional responsiveness to diverse extracellular signals.Molecular and cellular biology · 2012Article
- Regulation of human RNA polymerase III transcription by DNMT1 and DNMT3a DNA methyltransferases.The Journal of biological chemistry · 2012Article
- RNA polymerase III transcription in cancer: the BRF2 connection.Molecular cancer · 2011Review
- One function--multiple mechanisms: the manifold activities of p53 as a transcriptional repressor.Journal of biomedicine & biotechnology · 2011Review
- p53 Interacts with RNA polymerase II through its core domain and impairs Pol II processivity in vivo.PloS one · 2011Article
- The nucleolus under stress.Molecular cell · 2010Review
- Transcriptional regulation by p53.Cold Spring Harbor perspectives in biology · 2010Review
- TLS inhibits RNA polymerase III transcription.Molecular and cellular biology · 2010Article
- Article
- PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex.Molecular and cellular biology · 2008Article
- Transcriptional regulation of human small nuclear RNA genes.Biochimica et biophysica acta · 2008Review
- PNRC is a unique nuclear receptor coactivator that stimulates RNA polymerase III-dependent transcription.Journal of molecular signaling · 2007Article
- RNA polymerase III transcription is repressed in response to the tumour suppressor ARF.Nucleic acids research · 2007Article
- Article
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2 authors at 1 institution in 1 country.
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Abstract
Human U1 and U6 snRNA genes are transcribed by RNA polymerases II and III, respectively. While the p53 tumor suppressor protein is a general repressor of RNA polymerase III transcription, whether p53 regulates snRNA gene transcription by RNA polymerase II is uncertain. The data presented herein indicate that p53 is an effective repressor of snRNA gene transcription by both polymerases. Both U1 and U6 transcription in vitro is repressed by recombinant p53, and endogenous p53 occupancy at these promoters is stimulated by UV light. In response to UV light, U1 and U6 transcription is strongly repressed. Human U1 genes, but not U6 genes, contain a high-affinity p53 response element located within the core promoter region. Nonetheless, this element is not required for p53 repression and mutant p53 molecules that do not bind DNA can maintain repression, suggesting a reliance on protein interactions for p53 promoter recruitment. Recruitment may be mediated by the general transcription factors TATA-box binding protein and snRNA-activating protein complex, which interact well with p53 and function for both RNA polymerase II and III transcription.
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