ArticleMolecular and cellular biology2005
Wing-to-Leg homeosis by spineless causes apoptosis regulated by Fish-lips, a novel leucine-rich repeat transmembrane protein.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- The cell-adhesion molecule Echinoid promotes tissue survival and separately restricts tissue overgrowth.Development (Cambridge, England) · 2025Article
- Visualization of binding patterns for five Leucine-rich repeat proteins in themicroPublication biology · 2019Article
- Transsynaptic Fish-lips signaling prevents misconnections between nonsynaptic partner olfactory neurons.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Genetic Architecture of Abdominal Pigmentation in Drosophila melanogaster.PLoS genetics · 2015Article
- Constraints, independence, and evolution of thermal plasticity: probing genetic architecture of long- and short-term thermal acclimation.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Hox targets and cellular functions.Scientifica · 2013Article
- Differential activity of Drosophila Hox genes induces myosin expression and can maintain compartment boundaries.PloS one · 2013Article
- A dp53/JNK-dependant feedback amplification loop is essential for the apoptotic response to stress in Drosophila.Cell death and differentiation · 2012Article
- Article
- Dioxin exposure disrupts the differentiation of mouse embryonic stem cells into cardiomyocytes.Toxicological sciences : an official journal of the Society of Toxicology · 2010Article
- Genomewide analysis of aryl hydrocarbon receptor binding targets reveals an extensive array of gene clusters that control morphogenetic and developmental programs.Environmental health perspectives · 2009Article
- RNAi-mediated knockdown showing impaired cell survival in Drosophila wing imaginal disc.Gene regulation and systems biology · 2009Article
- The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns.BMC genomics · 2007Article
- Regulation of the Drosophila distal antennal determinant spineless.Developmental biology · 2007Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
Abstract
Growth, patterning, and apoptosis are mutually interactive during development. For example, cells that select an abnormal fate in a developing field are frequently removed by apoptosis. An important issue in this process that needs to be resolved is the mechanism used by cells to discern their correct fate from an abnormal fate. In order to examine this issue, we developed an animal model that expresses the dioxin receptor homolog Spineless (Ss) ectopically in the Drosophila wing. The presence of mosaic clones ectopically expressing ss results in a local transformation of organ identity, homeosis, from wing into a leg or antenna. The cells with misspecified fates subsequently activate c-Jun N-terminal kinase to undergo apoptosis in an autonomous or nonautonomous manner depending on their position within the wing, suggesting that a cell-cell interaction is, at least in some cases, involved in the detection of misspecified cells. Similar position dependence is commonly observed when various homeotic genes controlling the body segments are ectopically expressed. The autonomous and nonautonomous apoptosis caused by ss is regulated by a novel leucine-rich repeat family transmembrane protein, Fish-lips (Fili) that interacts with surrounding normal cells. These data support a mechanism in which the lack of some membrane proteins helps to recognize the presence of different cell types and direct these cells to an apoptotic fate in order to exclude them from the normal developing field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.