ArticleMolecular and cellular biology2005
dDP is needed for normal cell proliferation.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 39 citations in OpenAlex.
- E2F regulation of theProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cell-cycle exit and stem cell differentiation are coupled through regulation of mitochondrial activity in the Drosophila testis.Cell reports · 2022Article
- Article
- The Krüppel-like factor Cabut has cell cycle regulatory properties similar to E2F1.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Rb family-independent activating E2F increases genome stability, promotes homologous recombination, and decreases non-homologous end joining.Mechanisms of development · 2020Article
- Differential requirement for dimerization partner DP between E2F-dependent activation of tumor suppressor and growth-related genes.Scientific reports · 2018Article
- E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression.Developmental cell · 2017Article
- Temporal remodeling of the cell cycle accompanies differentiation in the Drosophila germline.Developmental biology · 2017Article
- Roles for the Histone Modifying and Exchange Complex NuA4 in Cell Cycle Progression in Drosophila melanogaster.Genetics · 2016Article
- E2F function in muscle growth is necessary and sufficient for viability in Drosophila.Nature communications · 2016Article
- Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila.Development (Cambridge, England) · 2015Article
- Scalloped and Yorkie are required for cell cycle re-entry of quiescent cells after tissue damage.Development (Cambridge, England) · 2015Article
- The pro-apoptotic activity of Drosophila Rbf1 involves dE2F2-dependent downregulation of diap1 and buffy mRNA.Cell death & disease · 2014Article
- dREAM co-operates with insulator-binding proteins and regulates expression at divergently paired genes.Nucleic acids research · 2014Article
- Global analysis of induced transcription factors and cofactors identifies Tfdp2 as an essential coregulator during terminal erythropoiesis.Experimental hematology · 2014Article
- Loss of dE2F compromises mitochondrial function.Developmental cell · 2013Article
- The molecular chaperone Hsp90 is required for cell cycle exit in Drosophila melanogaster.PLoS genetics · 2013Article
- Evidence for autoregulation and cell signaling pathway regulation from genome-wide binding of the Drosophila retinoblastoma protein.G3 (Bethesda, Md.) · 2012Article
- Identification of E2F target genes that are rate limiting for dE2F1-dependent cell proliferation.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes.Molecular and cellular biology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
To gain insight into the essential functions of E2F, we have examined the phenotypes caused by complete inactivation of E2F and DP family members in Drosophila. Our results show that dDP requires dE2F1 and dE2F2 for DNA-binding activity in vitro and in vivo. In tissue culture cells and in mutant animals, the levels of dE2F and dDP proteins are strongly interdependent. In the absence of dDP, the levels of dE2F1 and dE2F2 decline dramatically, and vice versa. Accordingly, the cell cycle and transcriptional phenotypes caused by targeting dDP mimic the effects of targeting both dE2F1 and dE2F2 and are indistinguishable from the effects of inactivating all three proteins. Although trans-heterozygous dDP mutant animals develop to late pupal stages, the analysis of somatic mutant clones shows that dDP mutant cells are at a severe proliferative disadvantage when compared directly with wild-type neighbors. Strikingly, the timing of S-phase entry or exit is not delayed in dDP mutant clones, nor is the accumulation of cyclin A or cyclin B. However, the maximal level of bromodeoxyuridine incorporation is reduced in dDP mutant clones, and RNA interference experiments show that dDP-depleted cells are prone to stall in S phase. In addition, dDP mutant clones contain reduced numbers of mitotic cells, indicating that dDP mutant cells have a defect in G2/M-phase progression. Thus, dDP is not essential for developmental control of the G1-to-S transition, but it is required for normal cell proliferation, for optimal DNA synthesis, and for efficient G2/M progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.