ArticleProceedings of the National Academy of Sciences of the United States of America2005
Cytolysin-dependent evasion of lysosomal killing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 77 citations in OpenAlex.
- Streptolysin O accelerates the conversion of plasminogen to plasmin.Nature communications · 2024Article
- The skin I live in: Pathogenesis of white-nose syndrome of bats.PLoS pathogens · 2024Review
- Pathogenic strategies ofScience (New York, N.Y.) · 2024Article
- Group AInfection and immunity · 2024Article
- Interplay between group AMicrobiology and molecular biology reviews : MMBR · 2024Review
- Role of serotype and virulence determinants ofFrontiers in cellular and infection microbiology · 2023Article
- A Role of Epithelial Cells and Virulence Factors in Biofilm Formation by Streptococcus pyogenesInfection and immunity · 2020Article
- An anti-perfringolysin O monoclonal antibody cross-reactive with streptolysin O protects against streptococcal toxic shock syndrome.BMC research notes · 2020Article
- Current Understanding of Group A Streptococcal Biofilms.Current drug targets · 2019Review
- Group A Streptococcus encounters with host macrophages.Future microbiology · 2018Review
- A Red Blood Cell Membrane-Camouflaged Nanoparticle Counteracts StreptolysinFrontiers in pharmacology · 2017Article
- Article
- NAD+-Glycohydrolase Promotes Intracellular Survival of Group A Streptococcus.PLoS pathogens · 2016Article
- Plasticity of neutrophils reveals modulatory capacity.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015Review
- A MyD88-JAK1-STAT1 complex directly induces SOCS-1 expression in macrophages infected with Group A Streptococcus.Cellular & molecular immunology · 2015Article
- Dynamin inhibition interferes with inflammasome activation and cytokine gene expression in Streptococcus pyogenes-infected human macrophages.Clinical and experimental immunology · 2014Article
- Article
- Streptococcus pyogenes biofilm growth in vitro and in vivo and its role in colonization, virulence, and genetic exchange.The Journal of infectious diseases · 2014Article
- Disease manifestations and pathogenic mechanisms of Group A Streptococcus.Clinical microbiology reviews · 2014Review
- Structural studies of Streptococcus pyogenes streptolysin O provide insights into the early steps of membrane penetration.Journal of molecular biology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Local host defenses limit proliferation and systemic spread of pathogenic bacteria from sites of mucosal colonization. For pathogens such as streptococci that fail to grow intracellularly, internalization and killing by epithelial cells contribute to the control of bacterial growth and dissemination. Here, we show that group A Streptococcus (GAS), the agent of streptococcal sore throat and invasive soft tissue infections, evades internalization and intracellular killing by pharyngeal epithelial cells. Production of the cholesterol-binding cytotoxin streptolysin O (SLO) prevented internalization of GAS into lysosomes. In striking contrast, GAS rendered defective in production of SLO were internalized directly or rapidly transported into lysosomes, where they were killed by a pH-dependent mechanism. Because SLO is the prototype of cholesterol-dependent cytolysins produced by many Gram-positive bacteria, cytolysin-mediated evasion of lysosomal killing may be a general mechanism to protect such pathogens from clearance by host epithelial cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.