ArticleThe Journal of cell biology2005
{beta}1 Integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Sulfatide Acts as a Regulatory Molecule Controlling β1 Integrin-STAT5 Signaling and BOLA2-Dependent Apoptotic Pathway in Breast Cancer Cells.International journal of molecular sciences · 2025Article
- Activated Stat5 trafficking Via Endothelial Cell-derived Extracellular Vesicles Controls IL-3 Pro-angiogenic Paracrine Action.Scientific reports · 2016Article
- Importance of the stem cell microenvironment for ophthalmological cell-based therapy.World journal of stem cells · 2015Review
- Extracellular matrix: a dynamic microenvironment for stem cell niche.Biochimica et biophysica acta · 2014Review
- Integrins in development and cancer.Biophysical reviews · 2014Review
- miR-221/222 control luminal breast cancer tumor progression by regulating different targets.Cell cycle (Georgetown, Tex.) · 2014Article
- Membrane-bound KIT ligand-targeting DNA vaccination inhibits mammary tumor growth.Oncoimmunology · 2014Article
- Activation of integrin-ERBB2 signaling in undifferentiated thyroid cancer.American journal of cancer research · 2014Article
- CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration.PloS one · 2013Article
- Article
- Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing.The Journal of biological chemistry · 2011Article
- MIR221/MIR222-driven post-transcriptional regulation of P27KIP1 and P57KIP2 is crucial for high-glucose- and AGE-mediated vascular cell damage.Diabetologia · 2011Article
- Integrin signalling adaptors: not only figurants in the cancer story.Nature reviews. Cancer · 2010Review
- Microarray study of mechanism of trichostatin a inducing apoptosis of Molt-4 cells.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2009Article
- Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation.Cancer research · 2009Article
- Integrins and cell-fate determination.Journal of cell science · 2009Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously demonstrated that integrin-dependent adhesion activates STAT5A, a well known target of IL-3-mediated signaling. Here, we show that in endothelial cells the active beta1 integrin constitutively associates with the unphosphorylated IL-3 receptor (IL-3R) beta common subunit. This association is not sufficient for activating downstream signals. Indeed, only upon fibronectin adhesion is Janus Kinase 2 (JAK2) recruited to the beta1 integrin-IL-3R complex and triggers IL-3R beta common phosphorylation, leading to the formation of docking sites for activated STAT5A. These events are IL-3 independent but require the integrity of the IL-3R beta common. IL-3 treatment increases JAK2 activation and STAT5A and STAT5B tyrosine and serine phosphorylation and leads to cell cycle progression in adherent cells. Expression of an inactive STAT5A inhibits cell cycle progression upon IL-3 treatment, identifying integrin-dependent STAT5A activation as a priming event for IL-3-mediated S phase entry. Consistently, overexpression of a constitutive active STAT5A leads to anchorage-independent cell cycle progression. Therefore, these data provide strong evidence that integrin-dependent STAT5A activation controls IL-3-mediated proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.