ArticleJournal of virology2005
Plateau levels of viremia correlate with the degree of CD4+-T-cell loss in simian immunodeficiency virus SIVagm-infected pigtailed macaques: variable pathogenicity of natural SIVagm isolates.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Dynamics of natural and pharmacologic control of an SIV variant with an envelope trafficking defect.The Journal of experimental medicine · 2026Article
- Genetic adaptations to SIV across chimpanzee populations.PLoS genetics · 2022Article
- Walk on the wild side: SIV infection in African non-human primate hosts-from the field to the laboratory.Frontiers in immunology · 2022Review
- Epigenetic silencing of CD4 expression in nonpathogenic SIV infection in African green monkeys.JCI insight · 2020Article
- Lymph Node Cellular and Viral Dynamics in Natural Hosts and Impact for HIV Cure Strategies.Frontiers in immunology · 2018Review
- Ancient hybridization and strong adaptation to viruses across African vervet monkey populations.Nature genetics · 2017Article
- Interleukin-2 Therapy Induces CD4 Downregulation, Which Decreases Circulating CD4 T Cell Counts, in African Green Monkeys.Journal of virology · 2016Article
- Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif.Journal of virology · 2015Article
- Homeostatic cytokines induce CD4 downregulation in African green monkeys independently of antigen exposure to generate simian immunodeficiency virus-resistant CD8αα T cells.Journal of virology · 2014Article
- Pathogenic features associated with increased virulence upon Simian immunodeficiency virus cross-species transmission from natural hosts.Journal of virology · 2014Article
- Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- HIV-associated chronic immune activation.Immunological reviews · 2013Review
- Old world monkeys and new age science: the evolution of nonhuman primate systems virology.ILAR journal · 2013Review
- Kinetics of myeloid dendritic cell trafficking and activation: impact on progressive, nonprogressive and controlled SIV infections.PLoS pathogens · 2013Article
- Article
- Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques.Journal of virology · 2012Article
- Immunovirological analyses of chronically simian immunodeficiency virus SIVmnd-1- and SIVmnd-2-infected mandrills (Mandrillus sphinx).Journal of virology · 2011Article
- Phylogenetic approach reveals that virus genotype largely determines HIV set-point viral load.PLoS pathogens · 2010Article
- Review
- HIV-1 transmitting couples have similar viral load set-points in Rakai, Uganda.PLoS pathogens · 2010Article
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Authors and funding
7 authors.
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Abstract
Simian immunodeficiency virus from African green monkeys (SIVagm) results in asymptomatic infection in its natural host species. The virus is not inherently apathogenic, since infection of pigtailed (PT) macaques (Macaca nemestrina) with one isolate of SIVagm results in an immunodeficiency syndrome characterized by progressive CD4+-T-cell depletion and opportunistic infections. This virus was passaged once in a PT macaque and, thus, may not be entirely reflective of the virulence of the parental strain. The goal of the present study was to assess the pathogenicity of the PT-passaged isolate (SIVagm9063) and two primary SIVagm isolates in PT macaques, including the parental strain of the PT-passaged variant. Infection of macaques with any of the three isolates resulted in high levels of primary plasma viremia by 1 week after inoculation. Viremia was quickly controlled following infection with SIVagm155; these animals have maintained CD4+-T-cell subsets and remain healthy. The plateau levels among SIVagm90- and SIVagm9063-inoculated macaques varied widely from 100 to 1 million copies/ml of plasma. Three of four animals from each of these groups progressed to AIDS. Setpoint viremia and the degree of CD4+-T-cell loss at 6 months postinfection were not significantly different between macaques inoculated with SIVagm90 and SIVagm9063. However these parameters were significantly different in SIVagm155-inoculated macaques (P values of <0.01). Considering all the macaques, the degree of CD4+-T-cell loss by 6 months postinfection correlated with the plateau levels of viremia. Thus, similar to SIVsm/mac infection of macaques and human AIDS, viral load is an excellent prognostic indicator of disease course. The inherent pathogenicity of natural SIVagm isolates varies, but such natural isolates are capable of inducing AIDS in macaques without prior macaque passage.
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