Evidence map›Paper›PMID 15794910›Full record

ReviewCurrent diabetes reports2005

Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications.

Yizhen Xu, Zhiheng He, George L King

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current diabetes reports, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Anti-Inflammatory Effects of SGLT2 Inhibitors: Focus on Macrophages.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
  6. Assessment of the antidiabetic potential of extract and novel phytoniosomes formulation of Tradescantia pallida leaves in the alloxan-induced diabetic mouse model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Antidiabetic effects ofFood science & nutrition · 2016
    Article
  14. Article
  15. Article
  16. Hypolipidemic Activity of Chloroform Extract of Mimosa pudica Leaves.Avicenna journal of medical biotechnology · 2010
    Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yizhen XuJoslin Diabetes Center, Harvard Medical School, One Joslin Place, Room 4504, Boston, MA 02215, USA.
Zhiheng He
George L King
Harvard University · US

Funding

SELECTIVE INSULIN RESISTANCE--DIABETIC VASCULAR DISEASER01DK053105 · NIDDK · JOSLIN DIABETES CENTER · PI KING, GEORGE L · 1997 to 2017
$5.0M
PROTEIN KINASE C ACTIVATION AND DIABETIC CARDIOMYOPATHYR01DK059725 · NIDDK · JOSLIN DIABETES CENTER · PI KING, GEORGE L · 2000 to 2004
$2.1M
NIDDK NIH HHS R01 DK53105NIDDK NIH HHS R01 DK59725
6 · The paper itself

Abstract

Hyperglycemia and dyslipidemia are significant and independent risk factors for the vascular complications in patients with diabetes. They have been suggested to cause cardiovascular pathologic changes in diabetic states through the following molecular mechanisms: formation and accumulation of advanced glycation end products; increased oxidative stress; activation of protein kinase C pathway; increased activity of hexosamine pathway; and vascular inflammation and the impairment of insulin action in the vascular tissues.

Indexed as

Diabetic AngiopathiesGlycation End Products, AdvancedHexosaminesHumansHyperglycemiaHyperlipidemiasInflammationInsulinOxidative StressProtein Kinase CGlycation End Products, AdvancedHexosaminesInsulinProtein Kinase C

Identifiers

PMID15794910
OpenAlexW2138745729

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.