ArticleNucleic acids research1992
In Euglena, spliced-leader RNA (SL-RNA) and 5S rRNA genes are tandemly repeated.
Article in Nucleic acids research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 32 citations in OpenAlex.
- Transcriptomic and genomic identification of spliceosomal genes fromActa biochimica et biophysica Sinica · 2023Article
- Article
- 5S rRNA gene arrangements in protists: a case of nonadaptive evolution.Journal of molecular evolution · 2012Review
- Diversity of Eukaryotic Translational Initiation Factor eIF4E in Protists.Comparative and functional genomics · 2012Article
- Convergent origins and rapid evolution of spliced leader trans-splicing in metazoa: insights from the ctenophora and hydrozoa.RNA (New York, N.Y.) · 2010Article
- U3 snoRNA genes are multi-copy and frequently linked to U5 snRNA genes in Euglena gracilis.BMC genomics · 2009Article
- Analysis of intergenic spacer transcripts suggests 'read-around' transcription of the extrachromosomal circular rDNA in Euglena gracilis.Nucleic acids research · 2001Article
- Evolutionary appearance of genes encoding proteins associated with box H/ACA snoRNAs: cbf5p in Euglena gracilis, an early diverging eukaryote, and candidate Gar1p and Nop10p homologs in archaebacteria.Nucleic acids research · 2000Article
- U1 small nuclear RNA and spliceosomal introns in Euglena gracilis.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Characterization of the unique intron-exon junctions of Euglena gene(s) encoding the polyprotein precursor to the light-harvesting chlorophyll a/b binding protein of photosystem II.Nucleic acids research · 1994Article
- Conversion of a trans-spliced C. elegans gene into a conventional gene by introduction of a splice donor site.The EMBO journal · 1993Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1992Article
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In Euglena gracilis, a 26 nucleotide leader sequence (spliced leader sequence = SL) is transferred by trans-splicing to the 5' end of a vast majority of cytoplasmic mRNAs (8). The SL originates from the 5' extremity of a family of closely related snRNAs (SL-RNAs) which are about 100 nucleotide long. In this paper we present the nucleotide sequences of two SL-RNA genes, confirming the sequences previously established by sequencing purified SL-RNAs. Although some SL-RNA genes are dispersed throughout the genome, we show that the majority of SL-RNA genes are located on 0.6 kb repeated units which also encode the cytoplasmic 5S rRNA. We estimate that the copy number of these repeated units is about 300 per haploid genome. The association of SL-RNA and 5S rRNA genes in tandemly repeated units is also found in nematodes but paradoxically does not exist in trypanosomes which are phylogenically much closer to Euglena. We also show that a high number of sequences analogous to the 26 nucleotide SL are dispersed throughout the genome and are not associated with SL-RNAs.
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