ArticleAntimicrobial agents and chemotherapy2005
Effects of age and sex on single-dose pharmacokinetics of tigecycline in healthy subjects.
Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Population Pharmacokinetics of Tigecycline and Implications for Individualized Therapy Optimization: A Systematic Review.Drug design, development and therapy · 2025Pooled it
- Population Pharmacokinetics of Tigecycline: A Systematic Review.Drug design, development and therapy · 2022Pooled it
- Tigecycline does not prolong corrected QT intervals in healthy subjects.Antimicrobial agents and chemotherapy · 2013Trial
- Population pharmacokinetics of tigecycline in patients with complicated intra-abdominal or skin and skin structure infections.Antimicrobial agents and chemotherapy · 2006Trial
- A multicenter trial of the efficacy and safety of tigecycline versus imipenem/cilastatin in patients with complicated intra-abdominal infections [Study ID Numbers: 3074A1-301-WW; ClinicalTrials.gov Identifier: NCT00081744].BMC infectious diseases · 2005Trial
- An insight into pharmacokinetics and dose optimization of antimicrobials agents in elderly patients.Frontiers in pharmacology · 2024Review
- Review
- Monte Carlo simulation evaluation of tigecycline dosing for bacteria with raised minimum inhibitory concentrations in non-critically ill adults.European journal of clinical pharmacology · 2021Article
- Pharmacokinetics of tigecycline in critically ill patients with liver failure defined by maximal liver function capacity test (LiMAx).Annals of intensive care · 2020Article
- A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia.Cancer medicine · 2016Article
- Tigecycline use in the outpatient parenteral antibiotic therapy setting.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Pharmacokinetics and safety of recently approved drugs used to treat methicillin-resistant Staphylococcus aureus infections in infants, children and adults.Expert review of clinical pharmacology · 2014Review
- Potential role of tigecycline in the treatment of community-acquired bacterial pneumonia.Infection and drug resistance · 2011Article
- Comparison of the pharmacokinetic properties of vancomycin, linezolid, tigecyclin, and daptomycin.European journal of medical research · 2010Article
- Antimalarial activity of tigecycline, a novel glycylcycline antibiotic.Antimicrobial agents and chemotherapy · 2009Article
- Clinical pharmacokinetics and pharmacodynamics of tigecycline.Clinical pharmacokinetics · 2009Review
- Tigecycline in the treatment of complicated intra-abdominal and complicated skin and skin structure infections.Therapeutics and clinical risk management · 2007Article
- In vitro activity of tigecycline against Burkholderia pseudomallei and Burkholderia thailandensis.Antimicrobial agents and chemotherapy · 2006Article
- Tigecycline (Tygacil): the first in the glycylcycline class of antibiotics.Proceedings (Baylor University. Medical Center) · 2006Article
- Tigecycline: an evidence-based review of its antibacterial activity and effectiveness in complicated skin and soft tissue and intraabdominal infections.Core evidence · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pharmacokinetics of tigecycline was evaluated in 46 healthy young and elderly men and women. Except for the volumes of distribution at steady state (approximately 350 liters in women versus 500 liters in men), there were no significant differences in tigecycline pharmacokinetic parameters. Based on pharmacokinetics, no dosage adjustment is warranted based on age or sex.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.