Trial reportAntimicrobial agents and chemotherapy2005
Effect of mupirocin treatment on nasal, pharyngeal, and perineal carriage of Staphylococcus aureus in healthy adults.
Trial report in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Dutch guideline on the laboratory detection of methicillin-resistant Staphylococcus aureus.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Guideline
- Chlorhexidine and Mupirocin for Clearance of Methicillin-Resistant Staphylococcus aureus Colonization After Hospital Discharge: A Secondary Analysis of the Changing Lives by Eradicating Antibiotic Resistance Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Trial
- Decolonization to Reduce Postdischarge Infection Risk among MRSA Carriers.The New England journal of medicine · 2019Trial
- Trial
- Targeted intranasal mupirocin to prevent colonization and infection by community-associated methicillin-resistant Staphylococcus aureus strains in soldiers: a cluster randomized controlled trial.Antimicrobial agents and chemotherapy · 2007Trial
- Sex-Specific Associations Between Smokeless Tobacco Use andTobacco use insights · 2026Article
- Antibiotic Resistance ofPharmaceuticals (Basel, Switzerland) · 2025Review
- Cutting Periprosthetic Infection Rate:Journal of clinical medicine · 2024Review
- Staphylococcus aureus colonisation and strategies for decolonisation.The Lancet. Microbe · 2024Review
- Bleach baths enhance skin barrier, reduce itch but do not normalize skin dysbiosis in atopic dermatitis.Archives of dermatological research · 2023Article
- The Role ofInternational journal of molecular sciences · 2022Review
- Superantigens, a Paradox of the Immune Response.Toxins · 2022Review
- APTC-C-SA01: A Novel Bacteriophage Cocktail TargetingInternational journal of molecular sciences · 2022Article
- Genomic Analysis of Community Transmission Networks for MRSA Among Females Entering a Large Inner-city Jail.Open forum infectious diseases · 2022Article
- Long-Term Sinonasal Carriage ofMicroorganisms · 2021Article
- Modulation of Allergic Sensitization and Allergic Inflammation byFrontiers in immunology · 2020Article
- Interplay of nasal and rectal carriage of Staphylococcus aureus in intensive care unit patients.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
- A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity.Nature communications · 2019Article
- Review
- Antimicrobial approaches in the prevention of Staphylococcus aureus infections: a review.The Journal of antimicrobial chemotherapy · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nasal carriage of Staphylococcus aureus is an important risk factor for S. aureus infections. Mupirocin nasal ointment is presently the treatment of choice for decolonizing the anterior nares. However, recent clinical trials show limited benefit from mupirocin prophylaxis in preventing nosocomial S. aureus infections, probably due to (re)colonization from extranasal carriage sites. Therefore, we studied the effectiveness of mupirocin nasal ointment treatment on the dynamics of S. aureus nasal and extranasal carriage. Twenty noncarriers, 26 intermittent carriers, and 16 persistent carriers had nasal, throat, and perineum samples taken 1 day before and 5 weeks after mupirocin treatment (twice daily for 5 days) and assessed for growth of S. aureus. The identities of cultured strains were assessed by restriction fragment length polymorphisms of the coagulase and protein A genes. The overall carriage rate (either nasal, pharyngeal, or perineal carrier or a combination) was significantly reduced after mupirocin treatment from 30 to 17 carriers (P = 0.003). Of the 17 carriers, 10 (60%) were still colonized with their old strain, 6 (35%) were colonized with an exogenous strain, and 1 (5%) was colonized with both. Two noncarriers became carriers after treatment. The acquisition of exogenous strains after mupirocin treatment is a common phenomenon. The finding warrants the use of mupirocin only in proven carriers for decolonization purposes. Mupirocin is effective overall in decolonizing nasal carriers but less effective in decolonizing extranasal sites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.