ArticleProceedings of the National Academy of Sciences of the United States of America2005
Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed.
- Control of the Development, Distribution, and Function of Innate-Like Lymphocytes and Innate Lymphoid Cells by the Tissue Microenvironment.Advances in experimental medicine and biology · 2024Review
- Insights into the heterogeneity of iNKT cells: tissue-resident and circulating subsets shaped by local microenvironmental cues.Frontiers in immunology · 2024Review
- Thymic development of human natural killer T cells: recent advances and implications for immunotherapy.Frontiers in immunology · 2024Review
- Markers and makers of NKT17 cells.Experimental & molecular medicine · 2023Review
- E protein binding at theFrontiers in immunology · 2023Article
- Decoupling the role of RORγt in the differentiation and effector function of TScience advances · 2022Article
- Differential blood leukocyte populations based on individual variances and age.Immunologic research · 2022Article
- Development of αβ T Cells with Innate Functions.Advances in experimental medicine and biology · 2022Article
- Modulation of TCR signalling components occurs prior to positive selection and lineage commitment in iNKT cells.Scientific reports · 2021Article
- Natural Killer T Lymphocytes Integrate Innate Sensory Information and Relay Context to Effector Immune Responses.Critical reviews in immunology · 2021Review
- Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge.Nature reviews. Immunology · 2020Review
- Nur77 controls tolerance induction, terminal differentiation, and effector functions in semi-invariant natural killer T cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- USP22 controls iNKT immunity through MED1 suppression of histone H2A monoubiquitination.The Journal of experimental medicine · 2020Article
- Impact of Aging on the Phenotype of Invariant Natural Killer T Cells in Mouse Thymus.Frontiers in immunology · 2020Article
- The zinc-finger transcription factor MAZR regulates iNKT cell subset differentiation.Cellular and molecular life sciences : CMLS · 2019Article
- SLAM-SAP-Fyn: Old Players with New Roles in iNKT Cell Development and Function.International journal of molecular sciences · 2019Review
- Transcription factor YY1 is essential for iNKT cell development.Cellular & molecular immunology · 2019Article
- The ins and outs of type I iNKT cell development.Molecular immunology · 2019Review
- Conditional Deletion of the V-ATPase a2-Subunit Disrupts Intrathymic T Cell Development.Frontiers in immunology · 2019Article
- Sumoylation of RORγt regulates TNature communications · 2018Article
6 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
T lineage commitment occurs in a discrete, stage-specific manner during thymic ontogeny. Intrathymic precursor transfer experiments and the identification of CD4(+)8+ double-positive (DP), V alpha 14J alpha 18 natural T (iNKT) cells suggest that commitment to this lineage might occur at the DP stage. Nevertheless, this matter remains contentious because others failed to detect V alpha 14J alpha 18-positive iNKT cells that are CD4(+)8+. In resolution to this issue, we demonstrate that retinoic acid receptor-related orphan receptor gamma (ROR gamma)0/0 thymi, which accumulate immature single-positive (ISP) thymocytes that precede the DP stage, do not rearrange V alpha 14-to-J alpha 18 gene segments, suggesting that this event occurs at a post-ISP stage. Mixed radiation bone marrow chimeras revealed that RORgamma functions in an iNKT cell lineage-specific manner. Further, introgression of a Bcl-x(L) transgene into ROR gamma(0/0) mice, which promotes survival and permits secondary rearrangements of distal V alpha and J alpha gene segments at the DP stage, rescues V alpha 14-to-J alpha 18 recombination. Similarly, introgression of a rearranged V alpha 14J alpha 18 transgene into ROR gamma(0/0) mice results in functional iNKT cells. Thus, our data support the "T cell receptor-instructive (mainstream precursor) model" of iNKT cell lineage specification where V alpha 14-to-J alpha 18 rearrangement, positive selection, and iNKT cell lineage commitment occur at or after the DP stage of ontogeny.
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