ArticleMolecular and cellular biochemistry2005
Paradoxical effects of hypoxia-mimicking divalent cobalt ions in human endothelial cells in vitro.
Article in Molecular and cellular biochemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 56 citations in OpenAlex.
- Improving cytocompatibility of Co28Cr6Mo by TiO2 coating: gene expression study in human endothelial cells.Journal of the Royal Society, Interface · 2013Trial
- Evaluating the potential hepatotoxicity from hip implant wear products-AnBiomaterials and biosystems · 2025Article
- Impact of Metal Ions on Cellular Functions: A Focus on Mesenchymal Stem/Stromal Cell Differentiation.International journal of molecular sciences · 2024Review
- Synergistic Antimicrobial Metal Oxide-Doped Phosphate Glasses; a Potential Strategy to Reduce Antimicrobial Resistance and Host Cell Toxicity.ACS biomaterials science & engineering · 2022Article
- Assessing the potential role of copper and cobalt in stimulating angiogenesis for tissue regeneration.PloS one · 2021Article
- Comprehensive transcriptomic profiling reveals SOX7 as an early regulator of angiogenesis in hypoxic human endothelial cells.The Journal of biological chemistry · 2020Article
- Cobalt-containing bioactive glasses reduce human mesenchymal stem cell chondrogenic differentiation despite HIF-1α stabilisation.Journal of the European Ceramic Society · 2018Article
- Interaction of Spin-Labeled Lipid Membranes with Transition Metal Ions.The journal of physical chemistry. B · 2015Article
- Bioactive Glasses: Frontiers and Challenges.Frontiers in bioengineering and biotechnology · 2015Review
- Engineering a microvascular capillary bed in a tissue-like collagen construct.Tissue engineering. Part A · 2014Article
- Glioma cells suppress hypoxia-induced endothelial cell apoptosis and promote the angiogenic process.International journal of oncology · 2007Article
- Characterisation of osteogenic and vascular responses of hMSCs to Ti-Co doped phosphate glass microspheres using a microfluidic perfusion platform.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Divalent cobalt ions (Co2+) induce the expression of hypoxia responsive genes and are often used in cell biology to mimic hypoxia. In this in vitro study we compared the effects of hypoxia and Co2+ on human endothelial cells and examined processes that are stimulated in hypoxia in vivo (proliferation and angiogenesis). We analyzed the expression of the hypoxia-inducible factor-1alpha (HIF-1alpha) under different hypoxic conditions (3% and nearly 0% O2) and Co2+ -concentrations (0.01-0.7 mM). As in hypoxia, the amount of HIF-1alpha protein was enhanced by exposure to Co2+ (did not correlate with mRNA amount). however, contrary to the results of hypoxia, in vitro-angiogenesis was inhibited after exposure to even low Co2+-concentrations (> or =0.01 mM). This led to the conclusion that although hypoxia signaling after Co2+ -exposure took place, further yet unknown Co2+ -induced event(s) must have occurred.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.