ArticleMolecular and cellular biochemistry2005
Compartmentation of energy metabolism in atrial myocardium of patients undergoing cardiac surgery.
Article in Molecular and cellular biochemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Atrial pacing improves mitochondrial function in peripheral blood mononuclear cells in patients with cardiac implantable electronic devices.American journal of physiology. Heart and circulatory physiology · 2024Article
- Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications.Nature reviews. Cardiology · 2024Review
- p38γ/δ activation alters cardiac electrical activity and predisposes to ventricular arrhythmia.Nature cardiovascular research · 2023Article
- The advantage of channeling nucleotides for very processive functions.F1000Research · 2017Review
- Mitochondrial Respiration in Human Colorectal and Breast Cancer Clinical Material Is Regulated Differently.Oxidative medicine and cellular longevity · 2017Article
- Simple oxygraphic analysis for the presence of adenylate kinase 1 and 2 in normal and tumor cells.Journal of bioenergetics and biomembranes · 2016Article
- Selective downregulation of mitochondrial electron transport chain activity and increased oxidative stress in human atrial fibrillation.American journal of physiology. Heart and circulatory physiology · 2016Article
- Fenofibrate inhibits atrial metabolic remodelling in atrial fibrillation through PPAR-α/sirtuin 1/PGC-1α pathway.British journal of pharmacology · 2016Article
- Mechanisms of arrhythmias and conduction disorders in older adults.Clinics in geriatric medicine · 2012Review
- Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a 'mitohormesis' mechanism involving reactive oxygen species and PGC-1.European heart journal · 2012Article
- Development of a novel proteomic approach for mitochondrial proteomics from cardiac tissue from patients with atrial fibrillation.Journal of proteome research · 2011Article
- Impaired oxidative phosphorylation in overtrained rat myocardium.Experimental and clinical cardiology · 2010Article
- Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart.Journal of the American College of Cardiology · 2009Article
- Impact of dietary fatty acids on cardiac arrhythmogenesis.Circulation. Arrhythmia and electrophysiology · 2009Review
- Mitochondria in the human heart.Journal of bioenergetics and biomembranes · 2009Review
- Energetic metabolism during acute stretch-related atrial fibrillation.Molecular and cellular biochemistry · 2008Article
- Atrophic gastritis: deficient complex I of the respiratory chain in the mitochondria of corpus mucosal cells.Journal of gastroenterology · 2008Article
- Structure-function relationships in the regulation of energy transfer between mitochondria and ATPases in cardiac cells.Experimental and clinical cardiology · 2006Article
- Intracellular energetic units in healthy and diseased hearts.Experimental and clinical cardiology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The parameters of oxidative phosphorylation and its interaction with creatine kinase (CK)- and adenylate kinase (AK)-phosphotransfer networks in situ were studied in skinned atrial fibers from 59 patients undergoing coronary artery bypass surgery, valve replacement/correction and atrial septal defect correction. In atria, the mitochondrial CK and AK are effectively coupled to oxidative phosphorylation, the MM-CK is coupled to ATPases and there exists a direct transfer of adenine nucleotides between mitochondria and ATPases. Elimination of cytoplasmic ADP with exogenous pyruvate kinase was not associated with a blockade of the stimulatory effects of creatine and AMP on respiration, neither could it abolish the coupling of MM-CK to ATPases and direct transfer of adenine nucleotides. Thus, atrial energy metabolism is compartmentalized so that mitochondria form functional complexes with adjacent ATPases. These complexes isolate a part of cellular adenine nucleotides from their cytoplasmic pool for participating in energy transfer via CK- and AK-networks, and/or direct exchange. Compared to atria in sinus rhythm, the fibrillating atria were larger and exhibited increased succinate-dependent respiration relative to glutamate-dependent respiration and augmented proton leak. Thus, alterations in mitochondrial oxidative phosphorylation may contribute to pathogenesis of atrial fibrillation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.