ArticleAmerican journal of human genetics2005
Increased level of linkage disequilibrium in rural compared with urban communities: a factor to consider in association-study design.
Article in American journal of human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Genetic ancestry and monogenic disease risk in the Scottish Traveller founder population.Nature communications · 2026Article
- Genetic effects on migration behavior contribute to increasing spatial differentiation at trait-associated loci in Estonia.iScience · 2025Article
- Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions.PLoS genetics · 2019Article
- The genetic landscape of Scotland and the Isles.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- An actionable KCNH2 Long QT Syndrome variant detected by sequence and haplotype analysis in a population research cohort.Scientific reports · 2019Article
- Genetic Geostatistical Framework for Spatial Analysis of Fine-Scale Genetic Heterogeneity in Modern Populations: Results from the KORA Study.International journal of genomics · 2015Article
- Human population structure, genome autozygosity and human health.Genome medicine · 2009Article
- Runs of homozygosity in European populations.American journal of human genetics · 2008Article
- Demographic changes and marker properties affect detection of human population differentiation.BMC genetics · 2007Article
- Another explanation for the low allergy rate in the rural Alpine foothills.Clinical and molecular allergy : CMA · 2005Article
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Authors and funding
7 authors.
Funding
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Abstract
Few studies have investigated genetic differentiation within nonisolate European populations, despite the initiation of large national sample collections such as U.K. Biobank. Here, we used short tandem repeat markers to explore fine-scale genetic structure and to examine the extent of linkage disequilibrium (LD) within national subpopulations. We studied 955 unrelated individuals of local ancestry from nine Scottish rural regions and the urban center of Edinburgh, as well as 96 unrelated individuals from the general U.K. population. Despite little overall differentiation on the basis of allele frequencies, there were clear differences among subpopulations in the extent of pairwise LD, measured between a subset of X-linked markers, that reflected presumed differences in the depths of the underlying genealogies within these subpopulations. Therefore, there are strategic advantages in studying rural subpopulations, in terms of increased power and reduced cost, that are lost by sampling across regions or within urban populations. Similar rural-urban contrasts are likely to exist in many other populations with stable rural subpopulations, which could influence the design of genetic association studies and national biobank data collections.
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