ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2005
Can routine laboratory tests discriminate between severe acute respiratory syndrome and other causes of community-acquired pneumonia?
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04062864 (Validity of Pupil Diameter for Pain Monitoring During General Anesthesia in Children), which is not on this map. Cited by 93 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Validity of Pupil Diameter for Pain Monitoring During General Anesthesia in Children : a Prospective Observational Study
Who cites it
93 citing papers in PubMed, 5 syntheses or guidelines pooled it, 197 citations in OpenAlex.
- Predictive Validity of Violence Screening Tools in Emergency and Psychiatric Services: A Systematic Review.Trauma, violence & abuse · 2026Pooled it
- The Diagnostic Utility of Host RNA Biosignatures in Adult Patients With Sepsis: A Systematic Review and Meta-Analysis.Critical care explorations · 2025Pooled it
- Pooled it
- Systematic review and meta-analysis of the diagnostic value of four biomarkers in detecting neonatal sepsis in low- and middle-income countries.BMJ paediatrics open · 2023Pooled it
- Comparing Single Case Design Overlap-Based Effect Size Metrics From Studies Examining Speech Generating Device Interventions.American journal on intellectual and developmental disabilities · 2016Pooled it
- Trial
- Regional Differences in Knee Osteoporosis Based on Coronal Alignment Phenotype in Patients Undergoing Preoperative CT Imaging.Diagnostics (Basel, Switzerland) · 2026Article
- Measurement of precipitated calcium citrate in 24-hour urine samples is clinically useful for ruling out calcium oxalate urolithiasis.Science progress · 2026Article
- Predicting Cardiac Magnetic Resonance-Derived Ejection Fraction from Echocardiogram Via Deep Learning Approach in Tetralogy of Fallot.Pediatric cardiology · 2026Article
- In-depth psychometric evaluation of the PsychQOL questionnaire: factor structure and ROC analysis.Frontiers in psychology · 2026Article
- Early prediction of plastic bronchitis in pediatric patients withFrontiers in cellular and infection microbiology · 2026Article
- Mapping risk of gambling disorder in older adults: a neural network approach.Frontiers in psychiatry · 2026Article
- A predictive model for household displacement duration after disasters.Risk analysis : an official publication of the Society for Risk Analysis · 2025Article
- Development of two indirect ELISAs using purified recombinant viral proteins to detect myxoma virus-antigen specific antibodies in rabbit sera.BMC veterinary research · 2025Article
- Predictive Validity and Cutoff Scores of the Revised Suicide Crisis Inventory in Korean Adults: A One-Year Follow-Up Study.Psychiatry investigation · 2025Article
- Screening Results and Performance of the CBCL Using a two-step Procedure for Mental Disorders in Chinese Children and Adolescents: a five-year Survey.The Psychiatric quarterly · 2025Article
- Performance of 4 Methods to Assess Health-Related Social Needs.JAMA network open · 2025Article
- Predicting Missed Appointments in Primary Care: A Personalized Machine Learning Approach.Annals of family medicine · 2025Article
- Potential Utility of Combined Presepsin and LDH Tracking for Predicting Therapeutic Efficacy of Steroid Pulse Therapy in Acute Exacerbation of Interstitial Lung Diseases: A Pilot Study.Journal of clinical medicine · 2025Article
- Predictive potential of combined secretomics and image-based morphometry as a non-invasive method for selecting implanting embryos.Reproductive biology and endocrinology : RB&E · 2025Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clinical presentation of severe acute respiratory syndrome (SARS) resembles that of other etiologies of community-acquired pneumonia, making diagnosis difficult. Hematological and biochemical abnormalities, particularly lymphopenia, are common in patients with SARS.
methodsWith the use of 2 databases, we compared the ability of the absolute lymphocyte count, absolute neutrophil count, lactate dehydrogenase level, creatine kinase level, alanine aminotransferase level, and serum calcium level at hospital admission to discriminate between cases of SARS and cases of community-acquired pneumonia. The SARS database contained data for 144 patients with SARS from the 2003 Toronto SARS outbreak. The community-acquired pneumonia database contained data for 8044 patients with community-acquired pneumonia from Edmonton, Canada. Patients from the SARS database were matched to patients from the community-acquired pneumonia database according to age, and receiver operating characteristic curves were constructed for each laboratory variable.
resultsThe areas under the receiver operating characteristic curves (AUCs) demonstrated fair to poor discriminatory ability for all laboratory variables tested except absolute neutrophil count, which had an AUC of 0.80, indicating good discriminatory ability (although there was no cutoff value of the absolute neutrophil count at which reasonable sensitivity or specificity could be obtained). Combinations of any 2 tests did not perform significantly better than did the absolute neutrophil count alone.
conclusionsRoutine laboratory tests, including determination of absolute lymphocyte count, should not be used in the diagnosis of SARS or incorporated into current case definitions of SARS. The role of the absolute neutrophil count in SARS diagnosis is likely limited, but it should be assessed further.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.