Trial reportThorax2005
Efficacy of low and high dose inhaled corticosteroid in smokers versus non-smokers with mild asthma.
Trial report in Thorax, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 66 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Double Blind, Placebo-controlled Three-way Crossover Study in Mild Asthmatics to Evaluate the Effect of Smoking Status on the Attenuation by Inhaled Corticosteroids of the Allergen-induced Asthmatic Response.
Small Airways Involvement in Smoker Asthmatic Patients: a Pilot Study
Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 279 citations in OpenAlex.
- Risk factors for asthma exacerbations during pregnancy: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2022Pooled it
- Inhaled corticosteroids and the risk of fractures in older adults: a systematic review and meta-analysis.Drug safety · 2008Pooled it
- Comparison of the efficacy of ciclesonide with that of budesonide in mild to moderate asthma patients after step-down therapy: a randomised parallel-group study.NPJ primary care respiratory medicine · 2014Trial
- Steroid resistance in COPD? Overlap and differential anti-inflammatory effects in smokers and ex-smokers.PloS one · 2014Trial
- 1-year prospective real life monitoring of asthma control and quality of life in Italy.Respiratory research · 2012Trial
- Effects of short-term treatment with atorvastatin in smokers with asthma--a randomized controlled trial.BMC pulmonary medicine · 2011Trial
- Randomised, double blind, placebo-controlled trial of selenium supplementation in adult asthma.Thorax · 2007Trial
- Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma.American journal of respiratory and critical care medicine · 2007Trial
- Misconceptions of Traits to Predict Response to Inhaled Corticosteroid and Bronchodilator Therapies in Asthma: A Narrative Review.Pulmonary therapy · 2026Review
- Smoking and Lung Function Response to Inhaled Glucocorticoids in Adult-Onset Asthma.Journal of asthma and allergy · 2026Article
- Real-life impact of anti-IL5 therapy on exacerbation types in patients with obstructive lung disease.BMJ open respiratory research · 2025Article
- Tobacco and asthma: presenting the world health organization (WHO) tobacco knowledge summary.Substance abuse treatment, prevention, and policy · 2025Review
- ''Unraveling the effects of smoking in asthmatic adolescents: clinical outcomes, spirometry findings, and risk analysis''.European journal of pediatrics · 2025Article
- Nrf2 Deficiency Accelerates IL-17-Dependent Neutrophilic Airway Inflammation in Asthmatic Mice.Antioxidants (Basel, Switzerland) · 2024Article
- Peri-Implant Inflammation in Waterpipe Users and Cigarette Smokers: An Observational Study.International dental journal · 2023Observational
- Pre-asthma: a useful concept for prevention and disease-modification? A EUFOREA paper. Part 1-allergic asthma.Frontiers in allergy · 2023Review
- Spatial, temporal and demographic patterns in asthma mortality in China: A systematic analysis from 2014 to 2020.The World Allergy Organization journal · 2023Article
- Asthma and Tobacco Smoking.Journal of personalized medicine · 2022Review
- Association of quality of life and disease control with cigarette smoking in patients with severe asthma.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022Article
- CpG oligodeoxynucleotides attenuate RORγt-mediated Th17 response by restoring histone deacetylase-2 in cigarette smoke-exposure asthma.Cell & bioscience · 2021Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCigarette smokers with asthma are insensitive to short term inhaled corticosteroid therapy, but efficacy when given for a longer duration at different doses is unknown.
methodsNinety five individuals with mild asthma were recruited to a multicentre, randomised, double blind, parallel group study comparing inhaled beclomethasone in doses of 400 microg or 2000 microg daily for 12 weeks in smokers and non-smokers. The primary end point was the change in morning peak expiratory flow (PEF). Secondary end points included evening PEF, use of reliever inhaler, number of asthma exacerbations, spirometric parameters, and asthma control score.
resultsAfter 12 weeks of inhaled beclomethasone there was a considerable difference between the morning PEF measurements of smokers and non-smokers with asthma (-18 (95% CI -35 to -1), adjusted p = 0.035). Among those receiving 400 microg daily there was a difference between the mean (95% CI) morning PEF (l/min) in smokers and non-smokers (-25 (95% CI -45 to -4), adjusted p = 0.019) and in the number of asthma exacerbations (6 v 1 in smokers and non-smokers, respectively, p = 0.007). These differences were reduced between smokers and non-smokers receiving 2000 microg inhaled beclomethasone daily.
conclusionsCompared with non-smokers, smokers with mild persistent asthma are insensitive to the therapeutic effect of low dose inhaled corticosteroid treatment administered for a 12 week period. The disparity of the response between smokers and non-smokers appears to be reduced with high dose inhaled corticosteroid. These findings have important implications for the management of individuals with mild asthma who smoke.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.