SynthesisThorax2005
Contribution of ADAM33 polymorphisms to the population risk of asthma.
Synthesis in Thorax, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- T1 polymorphism in a disintegrin and metalloproteinase 33 (ADAM33) gene may contribute to the risk of childhood asthma in Asians.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Pooled it
- Association of a disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms with the risk of COPD: an updated meta-analysis of 2,644 cases and 4,804 controls.Molecular biology reports · 2015Pooled it
- Association between ADAM33 T1 polymorphism and susceptibility to asthma in Asians.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Pooled it
- Role of ADAM and ADAMTS proteases in pathological tissue remodeling.Cell death discovery · 2023Review
- From gene identifications to therapeutic targets for asthma: Focus on great potentials ofChinese medical journal pulmonary and critical care medicine · 2023Review
- Article
- Association of ADAM33 gene polymorphisms with allergic asthma.Iranian journal of basic medical sciences · 2014Article
- Association study on ADAM33 polymorphisms in mite-sensitized persistent allergic rhinitis in a Chinese population.PloS one · 2014Article
- ADAM33 polymorphisms are associated with asthma and a distinctive palm dermatoglyphic pattern.Molecular medicine reports · 2013Article
- Association of ADAM33 gene polymorphisms with asthma in the Uygur population of China.Biomedical reports · 2013Article
- Unravelling the role of ADAM 33 in asthma.The Indian journal of medical research · 2013Article
- Regulation of a disintegrin and metalloprotease-33 expression by transforming growth factor-β.American journal of respiratory cell and molecular biology · 2012Article
- Association of ADAM33 gene polymorphisms with adult-onset asthma and its severity in an Indian adult population.Journal of genetics · 2011Article
- Role of ADAM33 gene and associated single nucleotide polymorphisms in asthma.Allergy & rhinology (Providence, R.I.) · 2011Article
- A Six-SNP haplotype of ADAM33 is associated with asthma in a population of Cartagena, Colombia.International archives of allergy and immunology · 2010Article
- Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population.BMC medical genetics · 2009Article
- The role of the epithelium in airway remodeling in asthma.Proceedings of the American Thoracic Society · 2009Review
- Association between SNP heterozygosity and quantitative traits in the Framingham Heart Study.Annals of human genetics · 2009Article
- Analyses of associations with asthma in four asthma population samples from Canada and Australia.Human genetics · 2009Article
- Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers.Respiratory research · 2009Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundADAM 33 is the first gene identified as a candidate for asthma by positional cloning techniques, with association studies reaching impressive statistical significance. It has a postulated role in myogenesis, airway modelling, and signalling via protein shedding. Concerns over the methodology of the initial study have led to several attempts at replication, with inconsistent results.
methodTo clarify the role of ADAM33 in determining the risk of asthma in the general population, new transmission disequilibrium and case-control studies were undertaken followed by a meta-analysis of all existing data.
resultsStudies in Icelandic and UK populations revealed no association when taken in isolation. The meta-analysis, however, showed that the F+1 and ST+7 variants were significantly associated with asthma in both types of study.
conclusionsThe additional risk imparted by this variation would account for 50,000 excess asthma cases in the UK alone. This study also demonstrates the size of study required to investigate such hypotheses adequately.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.