ArticleProceedings of the National Academy of Sciences of the United States of America2005
Dramatic variation of the vomeronasal pheromone receptor gene repertoire among five orders of placental and marsupial mammals.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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83 citing papers in PubMed, 197 citations in OpenAlex.
- The Role of Olfaction in Dogs: Evolution, Biology, and Human-Oriented Work.Animals : an open access journal from MDPI · 2026Review
- Chemosensory Receptors in Vertebrates: Structure and Computational Modeling Insights.International journal of molecular sciences · 2025Review
- Convergent reduction of olfactory genes and olfactory bulb size in mammalian species at altitude.Current biology : CB · 2025Article
- Diversity in chemosensory receptor genes in dogs and wolves: degeneration of the olfactory receptor gene repertoire in the brachycephalic Pug.Chemical senses · 2025Article
- Appeasing Substance Administration at Feedlot Entry Impacted Temperament, Pen Behavior, Immunocompetence, and Meat Quality of Beef Heifers.Animals : an open access journal from MDPI · 2024Article
- First Immunohistochemical Demonstration of the Expression of a Type-2 Vomeronasal Receptor, V2R2, in Wild Canids.International journal of molecular sciences · 2024Article
- Synchronized Expansion and Contraction of Olfactory, Vomeronasal, and Taste Receptor Gene Families in Hystricomorph Rodents.Molecular biology and evolution · 2024Article
- Effects of an Appeasing Substance Application at Weaning on Growth, Stress, Behavior, and Response to Vaccination ofAnimals : an open access journal from MDPI · 2023Article
- Administering an Appeasing Substance to Improve Performance, Neuroendocrine Stress Response, and Health of Ruminants.Animals : an open access journal from MDPI · 2022Review
- Notch signaling determines cell-fate specification of the two main types of vomeronasal neurons of rodents.Development (Cambridge, England) · 2022Article
- Does a third intermediate model for the vomeronasal processing of information exist? Insights from the macropodid neuroanatomy.Brain structure & function · 2022Article
- Strategic administration of an appeasing substance to improve performance and physiological responses of Bos indicus feedlot cattle.Journal of animal science · 2021Article
- The Chemosensory Repertoire of the Eastern Diamondback Rattlesnake (Crotalus adamanteus) Reveals Complementary Genetics of Olfactory and Vomeronasal-Type Receptors.Journal of molecular evolution · 2021Article
- A comprehensive structural, lectin and immunohistochemical characterization of the zebrafish olfactory system.Scientific reports · 2021Article
- Coding of pheromones by vomeronasal receptors.Cell and tissue research · 2021Review
- Distinct evolutionary trajectories of V1R clades across mouse species.BMC evolutionary biology · 2020Article
- Comparative genomic analyses illuminate the distinct evolution of megabats within Chiroptera.DNA research : an international journal for rapid publication of reports on genes and genomes · 2020Article
- Inactivation of ancV1R as a Predictive Signature for the Loss of Vomeronasal System in Mammals.Genome biology and evolution · 2020Article
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23 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Pheromones are chemicals emitted and sensed by conspecifics to elicit social and sexual responses and are perceived in terrestrial vertebrates primarily by the vomeronasal organ (VNO). Pheromone receptors in the mammalian VNO are encoded by the V1R and V2R gene superfamilies. The V1R superfamily contains 187 and 102 putatively functional genes in the mouse and rat, respectively. To investigate whether this large repertoire size is typical among mammals with functional VNOs, we here describe the V1R repertoires of dog, cow, and opossum based on their draft genome sequences. The dog and cow have only 8 and 32 intact V1R genes, respectively. Thus, the intact V1R repertoire size varies by at least 23-fold among placental mammals with functional VNOs. To our knowledge, this size ratio represents the greatest among-species variation in gene family size of all mammalian gene families. Phylogenetic analysis of placental V1R genes suggests multiple losses of ancestral genes in carnivores and artiodactyls and gains of many new genes by gene duplication in rodents, manifesting massive gene births and deaths. We also identify 49 intact opossum V1R genes and discover independent expansions of the repertoire in placentals and marsupials. We further show a concordance between the V1R repertoire size and the complexity of VNO morphology, suggesting that the latter could indicate the sophistication of pheromone communications within species. In sum, our results demonstrate tremendous diversity and rapid evolution of mammalian V1R gene inventories and caution the generalization of VNO biology from rodents to all mammals.
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