ArticleThe Journal of physiology2005
beta-Adrenoceptor-mediated long-term up-regulation of the release machinery at rat cerebellar GABAergic synapses.
Article in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Cross-talk between dopamine and noradrenaline modulates glutamatergic transmission in the deep cerebellar nuclei.Scientific reports · 2025Article
- Coordinated regulation of timing and strength of synaptic outputs by adrenergic receptors through control of action potentials in Purkinje cells.Frontiers in cellular neuroscience · 2025Article
- Presynaptic Adrenoceptors.Handbook of experimental pharmacology · 2024Review
- What Is the Role of Norepinephrine in Cerebellar Modulation and Stress-Induced Episodic Ataxia?Neurology · 2023Article
- Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergic neurotransmission and affect motor learning and behavioral functions.Frontiers in behavioral neuroscience · 2015Article
- Short-term potentiation of GABAergic synaptic inputs to vasopressin and oxytocin neurones.The Journal of physiology · 2014Article
- Neurotransmitter release during delay eyeblink classical conditioning: role of norepinephrine in consolidation and effect of age.Neurobiology of learning and memory · 2009Article
- Glutamatergic modulation of cerebellar interneuron activity is mediated by an enhancement of GABA release and requires protein kinase A/RIM1alpha signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Impaired GABAergic inhibition in the visual cortex of brain-derived neurotrophic factor heterozygous knockout mice.The Journal of physiology · 2008Article
- LTP of GABAergic synapses in the ventral tegmental area and beyond.The Journal of physiology · 2008Review
- Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha.Neuron · 2007Article
- Ambient GABA constrains the strength of GABAergic synapses at Cajal-Retzius cells in the developing visual cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Control of interneurone firing pattern by axonal autoreceptors in the juvenile rat cerebellum.The Journal of physiology · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Properly regulated interactions among excitatory and inhibitory synapses are critical for brain function. Compared to excitatory synapses, much less is known about the gain control mechanisms at inhibitory synapses. Herein we report a mechanism of noradrenergic long-term potentiation (LTP) at inhibitory synapses following presynaptic beta-adrenoceptor activation. Stimulation of beta-adrenoceptors elicited LTP of GABA release from terminals of cerebellar interneurones. This action was dependent on the cAMP/protein kinase A signalling cascade and independent of the beta-adrenoceptor-mediated acceleration of hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channel. Furthermore, the beta-adrenoceptor- and protein kinase A-mediated LTP was triggered by enhancement of the Ca2+ sensitivity of the release machinery and increase in the readily releasable pool. beta-Adrenoceptor activation also accelerated the recruitment of GABA into the releasable pool and enhanced synchronous and asynchronous release of GABA from the presynaptic terminal. Thus, the up-regulation of GABA release machinery mediated by noradrenaline and beta-adrenoceptor activation provides a likely mechanism of feedforward inhibition of the cerebellar output neurone Purkinje cell, leading to a profound effect on motor control and learning associated with the cerebellum.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.