ReviewHealth and quality of life outcomes2005
Measuring and reporting quality of life outcomes in clinical trials in cystic fibrosis: a critical review.
Review in Health and quality of life outcomes, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Patient-reported outcomes in randomized clinical trials: development of ISOQOL reporting standards.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2013Pooled it
- Measuring health-related quality of life in drug clinical trials: is it given due importance?Pharmacy world & science : PWS · 2008Pooled it
- Quality of life is associated with physical activity and fitness in cystic fibrosis.BMC pulmonary medicine · 2014Trial
- A first-year dornase alfa treatment impact on clinical parameters of patients with cystic fibrosis: the Brazilian cystic fibrosis multicenter study.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2013Trial
- Trial
- The Impact of Cost of Living on the Quality of Life of Cystic Fibrosis Patients: A Study in Greece.Cureus · 2024Article
- The Correlation of Health-Related Quality of Life with Cystic Fibrosis Severity Markers in Chest CT Scan and 6-Minute Walk Test: A Cross-Sectional Study.Indian journal of pediatrics · 2022Article
- TREATMENT ADHERENCE AMONG CHILDREN AND ADOLESCENTS IN A CYSTIC FIBROSIS REFERENCE CENTER.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2020Article
- Psychometric evaluation of the Swedish translation of the revised Cystic Fibrosis Questionnaire in adults.Upsala journal of medical sciences · 2017Article
- Flaxseed modulates inflammatory and oxidative stress biomarkers in cystic fibrosis: a pilot study.BMC complementary and alternative medicine · 2015Article
- Health-related quality of life in children with cystic fibrosis: validation of the German CFQ-R.Health and quality of life outcomes · 2009Article
- The evidence regarding exercise training in the management of cystic fibrosis: a systematic review.Cardiopulmonary physical therapy journal · 2008Article
- Health-related quality of life and patient-reported outcomes in pulmonary arterial hypertension.Proceedings of the American Thoracic Society · 2008Review
- Patient-reported outcomes in cystic fibrosis.Proceedings of the American Thoracic Society · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Good quality clinical trials are essential to inform the best cystic fibrosis (CF) management and care, by determining and comparing the effectiveness of new and existing therapies and drug delivery systems. The formal inclusion of quality of life (QoL) as an outcome measure in CF clinical trials is becoming more common. Both an appropriate QoL measure and sound methodology are required in order to draw valid inferences about treatments and QoL. A review was undertaken of randomised controlled trials in cystic fibrosis where QoL was measured. EMBASE, MEDLINE and ISI Web of Science were searched to locate all full papers in the English language reporting randomised controlled trials in cystic fibrosis, published between January 1991 and December 2004. All Cochrane reviews published before December 2004 were hand searched. Papers were included if the authors had reported that they had measured QoL or well being in the trial. 16 trials were identified. The interventions investigated were: antibiotics (4); home versus hospital administration of antibiotics (1); steroids (1); mucolytic therapies (6); exercise (3) and pancreatic enzymes (1). Not one trial evaluated in this review provided conclusive results concerning QoL. This review highlights many of the pitfalls of QoL measurement in CF clinical trials and provides constructive information concerning the design and reporting of trials measuring QoL.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.