ArticleBMC developmental biology2005
NXT2 is required for embryonic heart development in zebrafish.
Article in BMC developmental biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Posttranscriptional Regulation by Proteins and Noncoding RNAs.Advances in experimental medicine and biology · 2024Article
- Infection-experienced HSPCs protect against infections by generating neutrophils with enhanced mitochondrial bactericidal activity.Science advances · 2023Article
- Plexin D1 negatively regulates zebrafish lymphatic development.Development (Cambridge, England) · 2022Article
- Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer.Cancer discovery · 2021Article
- Roles for RNA export factor, Nxt1, in ensuring muscle integrity and normal RNA expression in Drosophila.G3 (Bethesda, Md.) · 2021Article
- CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- An F-Box Protein, Mdm30, Interacts with TREX Subunit Sub2 To Regulate Cellular Abundance Cotranscriptionally in Orchestrating mRNA Export Independently of Splicing and Mitochondrial Function.Molecular and cellular biology · 2020Article
- Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation.The Journal of clinical investigation · 2018Article
- Zebrafish as an Emerging Model Organism to Study Angiogenesis in Development and Regeneration.Frontiers in physiology · 2016Review
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- Evolutionary conservation of a molecular machinery for export and expression of mRNAs with retained introns.RNA (New York, N.Y.) · 2015Article
- FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling.Nature communications · 2014Article
- lyve1 expression reveals novel lymphatic vessels and new mechanisms for lymphatic vessel development in zebrafish.Development (Cambridge, England) · 2012Article
- Article
- Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fate.Developmental biology · 2010Article
- Knockdown of bicaudal C in zebrafish (Danio rerio) causes cystic kidneys: a nonmammalian model of polycystic kidney disease.Comparative medicine · 2010Article
- Article
- mRNA nuclear export at a glance.Journal of cell science · 2009Review
- Nkx2.7 and Nkx2.5 function redundantly and are required for cardiac morphogenesis of zebrafish embryos.PloS one · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundNXT2 is a member of NXT family proteins that are generally involved in exporting nuclear RNA in eukaryotic cells. It is not known if NXT2 has any function in specific biological processes.
resultsA zebrafish mutant exhibiting specific heart defects during embryogenesis was generated by animal cloning-mediated retroviral insertions. Molecular analysis indicated that the mutant phenotype was caused by a disruption of NXT2. Whole-mount RNA in situ hybridization showed that NXT2 transcripts were clearly detectable in embryonic heart as well as other tissues. Further analysis revealed that expression level of one form of alternative splicing NXT2 mRNA transcripts was significantly reduced, resulting in deficient myocardial cell differentiation and the malformation of cardiac valve at the atrioventricular boundary. The defects could be reproduced by morpholino anti-sense oligo knockdown of NXT2.
conclusionNXT2 has a critical role in maintaining morphogenetic integrity of embryonic heart in vertebrate species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.