ArticleThe Biochemical journal2005
Fibulin-5 interacts with fibrillin-1 molecules and microfibrils.
Article in The Biochemical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 103 citations in OpenAlex.
- Novel Aortic Dissection Model Links Endothelial Dysfunction and Immune Infiltration.Circulation research · 2025Article
- Extracellular matrix in skin diseases: The road to new therapies.Journal of advanced research · 2023Review
- Elastic Fibre Proteins in Elastogenesis and Wound Healing.International journal of molecular sciences · 2022Review
- Latent TGFβ complexes are transglutaminase cross-linked to fibrillin to facilitate TGFβ activation.Matrix biology : journal of the International Society for Matrix Biology · 2022Article
- Alveologenesis: What Governs Secondary Septa Formation.International journal of molecular sciences · 2021Review
- Role of Fibulins in Embryonic Stage Development and Their Involvement in Various Diseases.Biomolecules · 2021Review
- Dysregulated assembly of elastic fibers in fibulin-5 knockout mice results in a tendon-specific increase in elastic modulus.Journal of the mechanical behavior of biomedical materials · 2021Article
- Clinical and Molecular Delineation of Cutis Laxa Syndromes: Paradigms for Homeostasis.Advances in experimental medicine and biology · 2021Review
- Extracellular Interactions between Fibulins and Transforming Growth Factor (TGF)-β in Physiological and Pathological Conditions.International journal of molecular sciences · 2018Review
- Transglutaminase-2 promotes metastatic and stem-like phenotypes in osteosarcoma.American journal of cancer research · 2018Article
- Fibrillin-containing microfibrils are key signal relay stations for cell function.Journal of cell communication and signaling · 2015Article
- Fibulin-5 deficiency causes developmental defect of premaxillary bone in mice.Biochemical and biophysical research communications · 2015Article
- Is There a Relationship Between Pelvic Organ Prolapse and Tissue Fibrillin-1 Levels?International neurourology journal · 2015Article
- Function of latent TGFβ binding protein 4 and fibulin 5 in elastogenesis and lung development.Journal of cellular physiology · 2015Article
- Fibulin-4 and fibulin-5 in elastogenesis and beyond: Insights from mouse and human studies.Matrix biology : journal of the International Society for Matrix Biology · 2014Review
- Cutis laxa: intersection of elastic fiber biogenesis, TGFβ signaling, the secretory pathway and metabolism.Matrix biology : journal of the International Society for Matrix Biology · 2014Review
- Fibulin-3, -4, and -5 are highly susceptible to proteolysis, interact with cells and heparin, and form multimers.The Journal of biological chemistry · 2013Article
- Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Extracellular matrix molecules facilitating vascular biointegration.Journal of functional biomaterials · 2012Article
- The Role of the Endothelium in HPS Pathogenesis and Potential Therapeutic Approaches.Advances in virology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibulin-5 plays an important role in elastic fibre formation in vivo. We have investigated the molecular interactions between fibulin-5 and components of fibrillin-rich microfibrils which form a template for elastin. Fibulin-5 interacted in a dose-dependent manner with a fibrillin-1 N-terminal sequence and with tropoelastin, but not with MAGP-1 (microfibril-associated glycoprotein-1) or decorin. Fibulin-5 did not inhibit interactions between fibrillin-1 N- and C-terminal fragments, or fibrillin-1 interactions with tropoelastin. Fibulin-5 may provide a link between tropoelastin and microfibrils in the pericellular space during elastic fibre assembly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.