ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Distinct roles of calcineurin-nuclear factor of activated T-cells and protein kinase A-cAMP response element-binding protein signaling in presynaptic differentiation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Alternatively spliced STIM2.3 is an evolutionarily late store-operated Ca2+ entry regulator expressed in brain.Journal of cell science · 2026Article
- Axonal CB1 Receptors Mediate Inhibitory Bouton Formation via cAMP Increase and PKA.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Lipid Pathology of the Corpus Callosum in Schizophrenia and the Potential Role of Abnormal Gene Regulatory Networks with Reduced Microglial Marker Expression.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Extra-embryonic tissue spreading directs early embryo morphogenesis in killifish.Nature communications · 2017Article
- The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and Diseases.Journal of aging research · 2016Review
- Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Targets Down Syndrome Candidate Region 1 (DSCR1/RCAN1) to control Neuronal Differentiation.The Journal of biological chemistry · 2015Article
- A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons.Human molecular genetics · 2014Article
- Altered neural connectivity in excitatory and inhibitory cortical circuits in autism.Frontiers in human neuroscience · 2013Article
- Role of calcineurin in the VTA in rats behaviorally sensitized to methamphetamine.Psychopharmacology · 2012Article
- Calcineurin regulation of cytoskeleton organization: a new paradigm to analyse the effects of calcineurin inhibitors on the kidney.Journal of cellular and molecular medicine · 2012Review
- BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Embryonic origin of olfactory circuitry in Drosophila: contact and activity-mediated interactions pattern connectivity in the antennal lobe.PLoS biology · 2012Article
- IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Mitochondrial Ca2+ cycling facilitates activation of the transcription factor NFAT in sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- NFAT-3 is a transcriptional repressor of the growth-associated protein 43 during neuronal maturation.The Journal of biological chemistry · 2009Article
- The Role of Methionine Oxidation/Reduction in the Regulation of Immune Response.Current signal transduction therapy · 2009Article
- NFAT signaling in neural development and axon growth.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2008Review
- Neuronal calcium sensor proteins are unable to modulate NFAT activation in mammalian cells.Biochimica et biophysica acta · 2008Article
- Myosin Va controls oligodendrocyte morphogenesis and myelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Ca2+ signal summation and NFATc1 nuclear translocation in sympathetic ganglion neurons during repetitive action potentials.Cell calcium · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptic vesicle accumulation and morphological changes are characteristic features of axon terminal differentiation during synaptogenesis. To investigate the regulatory mechanism that orchestrates synaptic molecules to form mature presynaptic terminals, we visualized a single axon terminal of zebrafish olfactory sensory neurons in vivo and examined the effects of the neuron-specific gene manipulations on the axon terminal differentiation. Synaptic vesicles visualized with vesicle-associated membrane protein 2 (VAMP2)-enhanced green fluorescent protein (EGFP) fusion protein gradually accumulated in axon terminals, whereas the axon terminals visualized with GAP43 fused with EGFP remodeled from complex shapes with filopodia to simple shapes without filopodia from 50 h postfertilization (hpf) to 84 hpf. Expression of dominant-negative protein kinase A (PKA) or cAMP response element-binding protein (CREB) suppressed the VAMP2-EGFP punctum formation in axon terminals during synaptogenesis. Consistently, constitutively active PKA or CREB stimulated VAMP2-EGFP puncta formation. On the other hand, cyclosporine A treatment or suppression of nuclear factor of activated T cells (NFAT) activation prevented the axon terminal remodeling from complex to simple shapes during synaptogenesis. Consistently, expression of constitutively active calcineurin accelerated the axon terminal remodeling. These results suggest that calcineurin-NFAT signaling regulates axon terminal remodeling, and PKA-CREB signaling controls synaptic vesicle accumulation.
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Registered trials
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