ArticleProceedings of the National Academy of Sciences of the United States of America2005
Regulation of hematopoietic stem cell aging in vivo by a distinct genetic element.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 62 citations in OpenAlex.
- Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity.Haematologica · 2022Article
- The lifespan quantitative trait locus geneHaematologica · 2020Article
- Immunological aspects of age-related diseases.World journal of biological chemistry · 2017Review
- Quantitative trait gene Slit2 positively regulates murine hematopoietic stem cell numbers.Scientific reports · 2016Article
- Aging, Clonality, and Rejuvenation of Hematopoietic Stem Cells.Trends in molecular medicine · 2016Review
- Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing.Nature cell biology · 2016Article
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.Nature medicine · 2016Article
- Regulation of hematopoietic stem cell aging by the small RhoGTPase Cdc42.Experimental cell research · 2014Review
- Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury.Translational cancer research · 2013Article
- Cdc42 and aging of hematopoietic stem cells.Current opinion in hematology · 2013Review
- Article
- Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.Cell stem cell · 2012Article
- Human retinoblastoma binding protein 9, a serine hydrolase implicated in pancreatic cancers.Protein and peptide letters · 2012Review
- Article
- Polycomb group proteins in hematopoietic stem cell aging and malignancies.International journal of hematology · 2011Review
- RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Article
- Combining transcriptional profiling and genetic linkage analysis to uncover gene networks operating in hematopoietic stem cells and their progeny.Immunogenetics · 2008Review
- Article
- Aging stem cells, latexin, and longevity.Experimental cell research · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Until recently, stem cells were thought to be endowed with unlimited self-renewal capacity and, thus, assumed exempt from aging. But accumulating evidence over the past decade compellingly argues that a measurable and progressive replicative impairment in the hematopoietic, intestinal, and muscle stem cell activity exists from adulthood to old age, resulting in a decline in stem cell function and rendering stem cell aging as the possible link between cellular aging and organismal aging. By using a previously uncharacterized congenic animal model to study genetic regulation of hematopoietic stem cell aging, we have demonstrated definitively that a locus on murine chromosome 2 regulates hematopoietic stem cell aging. In addition to demonstrating that hematopoietic stem cell aging is regulated by a distinct genetic element, experimental evidence links the response of hematopoietic stem cells to DNA double-strand breaks to cellular aging, suggesting DNA integrity influences stem cell aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.