ReviewProceedings of the National Academy of Sciences of the United States of America2005
Contingent gene regulatory networks and B cell fate specification.
Review in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed.
- Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue.Scientific reports · 2017Trial
- Bipartite DNA binding domain of transcription factor BCL11B binds clustered short DNA sequence motifs.bioRxiv : the preprint server for biology · 2026Article
- An era of immunological discoveries heralded by molecular biology.Trends in immunology · 2025Article
- In vitro differentiation of common lymphoid progenitor cells into B cell using stromal cell free culture system.BMC immunology · 2025Article
- NFIXing Cancer: The Role of NFIX in Oxidative Stress Response and Cell Fate.International journal of molecular sciences · 2023Review
- Single-cell gene regulation network inference by large-scale data integration.Nucleic acids research · 2022Article
- Heterosis of fitness and phenotypic variance in the evolution of a diploid gene regulatory network.PNAS nexus · 2022Article
- Integrated bioinformatics analysis of the transcription factor-mediated gene regulatory networks in the formation of spermatogonial stem cells.Frontiers in physiology · 2022Article
- A regulatory network of microRNAs confers lineage commitment during early developmental trajectories of B and T lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Pre-mitotic genome re-organisation bookends the B cell differentiation process.Nature communications · 2021Article
- Deep learning of immune cell differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Charting the cis-regulome of activated B cells by coupling structural and functional genomics.Nature immunology · 2020Article
- The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Diminished antibody response to influenza vaccination is characterized by expansion of an age-associated B-cell population with low PAX5.Clinical immunology (Orlando, Fla.) · 2018Article
- Generation of an osteoblast-based artificial niche that supports in vitro B lymphopoiesis.Experimental & molecular medicine · 2017Article
- Developmentally regulated higher-order chromatin interactions orchestrate B cell fate commitment.Nucleic acids research · 2017Article
- The cellular and molecular determinants of emphysematous destruction in COPD.Scientific reports · 2017Article
- Early B Cell Progenitors Deficient for GON4L Fail To Differentiate Due to a Block in Mitotic Cell Division.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Cutting Edge: The Transcription Factor Sox2 Regulates AID Expression in Class-Switched B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The B cell developmental pathway represents a leading system for the analysis of regulatory circuits that orchestrate cell fate specification and commitment. Considerable progress has been achieved within the past decade in the identification and genetic analysis of various regulatory components. These components include the transcription factors PU.1, Ikaros, Bcl11a, E2A, EBF, and Pax-5, as well as the cytokine receptors Flk2 and IL-7R. Experimental evidence of connectivity among the regulatory components is used to assemble sequentially acting and contingent gene regulatory networks. Transient signaling inputs, self-sustaining positive feedback loops, and cross-antagonism among alternate cell fate determinants are key features of the proposed networks that instruct the development of B lymphocyte precursors from hematopoietic stem cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.