Evidence map›Paper›PMID 15788282›Full record

ArticleNeurocase2004

Clinical, cognitive and anatomical evolution from nonfluent progressive aphasia to corticobasal syndrome: a case report.

Maria Luisa Gorno-Tempini, Ryan C Murray, Katherine P Rankin, Michael W Weiner, Bruce L Miller

Abstract readCase Reports
In one paragraph

Article in Neurocase, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 138 citations in OpenAlex.

  1. Non-fluent agrammatic variant of primary progressive aphasia in a bilingual Mandarin/English speaker: a case report.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026
    Article
  2. Review
  3. Symptom-led staging for semantic and non-fluent/agrammatic variants of primary progressive aphasia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  4. Symptom-led staging for primary progressive aphasia.medRxiv : the preprint server for health sciences · 2023
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Language Breakdown in Primary Progressive Aphasias.Annals of Indian Academy of Neurology · 2020
    Article
  12. Longitudinal flortaucipir ([Cortex; a journal devoted to the study of the nervous system and behavior · 2020
    Article
  13. Prominent auditory deficits in primary progressive aphasia: A case study.Cortex; a journal devoted to the study of the nervous system and behavior · 2019
    Article
  14. Clinical Progression in Four Cases of Primary Progressive Apraxia of Speech.American journal of speech-language pathology · 2018
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Maria Luisa Gorno-TempiniDepartment of Neurology, University of California San Francisco, San Francisco, CA 94143-1207, USA. marilu@itsa.ucsf.edu
Ryan C Murray
Katherine P Rankin
Michael W Weiner
Bruce L Miller
University of California, San Francisco · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
NIA NIH HHS P01 AG019724NIA NIH HHS P50 AG023501
6 · The paper itself

Abstract

Recent clinical and pathological studies have suggested that frontotemporal lobar degeneration (FTLD) and corticobasal syndrome (CBS) show clinical and pathological overlap. We present four years of longitudinal clinical, cognitive and anatomical data in the case of a 56-year-old woman, AS, whose clinical picture evolved from FTLD to CBS. For the first three years, AS showed a progressive speech and language disorder compatible with a diagnosis of the nonfluent aphasia variant of FTLD. At year four, 10 years after her first symptom, AS developed the classical clinical signs of CBS, including alien limb phenomenon and dystonia. Voxel-based morphometry (VBM) applied to AS's four annual scans showed progression of atrophy from the inferior posterior frontal gyrus, to the left insula and finally to the medial frontal lobe. This case demonstrates the clinical overlap between FTLD and CBS and shows that the two can appear in the same patient at different stages of the disease in relation to the progression of anatomical damage.

Indexed as

Aphasia, BrocaApraxiasBasal GangliaBasal Ganglia DiseasesCognitionDisease ProgressionDystoniaFemaleFrontal LobeHandwritingHumansLanguage TestsMagnetic Resonance ImagingMiddle AgedNeurodegenerative DiseasesNeuropsychological Tests

Identifiers

PMID15788282
PMCPMC2365737
OpenAlexW2053723085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.