ArticleMolecular and cellular biochemistry2005
The L-type calcium channel alpha 1C subunit gene undergoes extensive, uncoordinated alternative splicing.
Article in Molecular and cellular biochemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- CaEuropean biophysics journal : EBJ · 2016Review
- Alternative splicing of Cav1.2 channel exons in smooth muscle cells of resistance-size arteries generates currents with unique electrophysiological properties.American journal of physiology. Heart and circulatory physiology · 2009Article
- Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand.Neuroscience · 2007Article
- Disrupting calcium channel expression to lower blood pressure: new targeting of a well-known channel.Molecular interventions · 2006Article
- Developmental activation of calmodulin-dependent facilitation of cerebellar P-type Ca2+ current.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The alpha1C subunit is the pore-forming protein for the L-type calcium channel. Previous studies indicate that there is possible tissue-specific alternative splicing of this gene. In this study we cloned the entire open reading frame of the alpha1C subunit cDNA from adult rat cardiac myocytes in a single piece (6.64 kb). Using 75 positive clones that were identified by restriction enzyme mapping, we tested the alternative splicing patterns of the Ca(v) 1.2 gene that encodes the alpha1C subunit protein and focused on five loci: IS6, post-IS6, IIIS2, IVS3, and the c-terminus. The results indicate that: (1) alternative splicing occurs in most of the loci, giving rise to two or three different isoforms at those sites; (2) there is a predominant form for each splicing site, (3) there does not appear to be consistent coordination of splicing at multiple loci of this gene. Alternative splicing is not tissue-specific in most regions.
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Registered trials
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