ArticleMolecular and cellular biochemistry2005
Interpretation of relevance of sodium-calcium exchange in action potential of diabetic rat heart by mathematical model.
Article in Molecular and cellular biochemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Cardiac digital twins: a tool to investigate the function and treatment of the diabetic heart.Cardiovascular diabetology · 2025Review
- Redox control of cardiac excitability.Antioxidants & redox signaling · 2013Review
- Altered gene expression may underlie prolonged duration of the QT interval and ventricular action potential in streptozotocin-induced diabetic rat heart.Molecular and cellular biochemistry · 2009Article
- Effects of streptozotocin-induced diabetes on action potentials in the sinoatrial node compared with other regions of the rat heart.Molecular and cellular biochemistry · 2007Article
- Safety and efficacy of catheter ablation of atrial fibrillation in patients with diabetes mellitus--single center experience.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2006Article
- Altered mechanical and electrical activities of the diabetic heart: Possible use of new therapeutics?Experimental and clinical cardiology · 2005Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Sarcolemmal Na+-Ca2+ exchange plays a central role in ion transport of the myocardium and the current carried with it contributes to the late phase of the action potential (AP) besides the contribution of outward K+-currents. In this study, the mathematical model for AP of the diabetic rat ventricular myocytes [34] was modified and used for the diabetic rat papillary muscle. We used our experimentally measured values of two K+-currents; transient outward current, Ito and steady-state outward current, Iss, as well as L-type Ca2+-current, I(CaL), then compared with the simulated values. We have demonstrated that the prolongation in the AP of the papillary muscle of the diabetic rats are not due to the alteration of I(CaL) but mainly due to the inhibition of the K+-currents and also the Na+-Ca2+ exchanger current, I(Na-Ca). In combination with our experimental data on sodium-selenite-treated diabetic rats, our simulation results provide new information concerning plausible ionic mechanisms, and second a possible positive effect of selenium treatment on the altered I(Na-Ca) for the observed changes in the AP duration of streptozotocin-induced diabetic rat heart.
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