ArticleJournal of molecular evolution2005
Single nucleotide +1 frameshifts in an apparently functional mitochondrial cytochrome b gene in ants of the genus Polyrhachis.
Article in Journal of molecular evolution, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 50 citations in OpenAlex.
- Mitochondrial Genomes in Perkinsus Decode Conserved Frameshifts in All Genes.Molecular biology and evolution · 2022Article
- Substantial rearrangements, single nucleotide frameshift deletion and low diversity in mitogenome of Wolbachia-infected strepsipteran endoparasitoid in comparison to its tephritid hosts.Scientific reports · 2022Article
- More discussion of minimalist species descriptions and clarifying some misconceptions contained in Meier et al. 2021.ZooKeys · 2022Article
- Multiple origins of a frameshift insertion in a mitochondrial gene in birds and turtles.GigaScience · 2021Article
- Prediction of mitochondrial genome-wide variation through sequencing of mitochondrion-enriched extracts.Scientific reports · 2020Article
- Unorthodox features in two venerid bivalves with doubly uniparental inheritance of mitochondria.Scientific reports · 2020Article
- Chimeric Translation for Mitochondrial Peptides: Regular and Expanded Codons.Computational and structural biotechnology journal · 2019Article
- Animal Mitochondrial DNA as We Do Not Know It: mt-Genome Organization and Evolution in Nonbilaterian Lineages.Genome biology and evolution · 2016Article
- Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.Nucleic acids research · 2016Review
- The Mitochondrial Genomes of Aquila fasciata and Buteo lagopus (Aves, Accipitriformes): Sequence, Structure and Phylogenetic Analyses.PloS one · 2015Article
- Control of gene expression by translational recoding.Advances in protein chemistry and structural biology · 2012Review
- Poly(T) variation in heteroderid nematode mitochondrial genomes is predominantly an artefact of amplification.Journal of molecular evolution · 2011Article
- A molecular phylogeny of bivalve mollusks: ancient radiations and divergences as revealed by mitochondrial genes.PloS one · 2011Article
- Article
- Extensive frameshift at all AGG and CCC codons in the mitochondrial cytochrome c oxidase subunit 1 gene of Perkinsus marinus (Alveolata; Dinoflagellata).Nucleic acids research · 2010Article
- The complete mitochondrial genomes of the whistling duck (Dendrocygna javanica) and black swan (Cygnus atratus): dating evolutionary divergence in Galloanserae.Molecular biology reports · 2010Article
- Recoding of translation in turtle mitochondrial genomes: programmed frameshift mutations and evidence of a modified genetic code.Journal of molecular evolution · 2008Article
- Poly(T) variation within mitochondrial protein-coding genes in Globodera (Nematoda: Heteroderidae).Journal of molecular evolution · 2008Article
- The mitochondrial genome of the hexactinellid sponge Aphrocallistes vastus: evidence for programmed translational frameshifting.BMC genomics · 2008Article
- A simplified explanation for the frameshift mutation that created a novel C-terminal motif in the APETALA3 gene lineage.BMC evolutionary biology · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Twelve of 30 species examined in the ant genus Polyrhachis carry single nucleotide insertions at one or two positions within the mitochondrial cytochrome b (cytb) gene. Two of the sites are present in more than one species. Nucleotide substitutions in taxa carrying insertions show the strong codon position bias expected of functional protein coding genes, with substitutions concentrated in the third positions of the original reading frame. This pattern of evolution of the sequences strongly suggests that they are functional cytb sequences. This result is not the first report of +1 frameshift insertions in animal mitochondrial genes. A similar site was discovered in vertebrates, where single nucleotide frameshift insertions in many birds and a turtle were reported by Mindell et al. (Mol Biol Evol 15:1568, 1998). They hypothesized that the genes are correctly decoded by a programmed frameshift during translation. The discovery of four additional sites gives us the opportunity to look for common features that may explain how programmed frameshifts can arise. The common feature appears to be the presence of two consecutive rare codons at the insertion site. We hypothesize that the second of these codons is not efficiently translated, causing a pause in the translation process. During the stall the weak wobble pairing of the tRNA bound in the peptidyl site of the ribosome, together with an exact Watson-Crick codon-anticodon pairing in the +1 position, allows translation to continue in the +1 reading frame. The result of these events is an adequate level of translation of a full-length and fully functional protein. A model is presented for decoding of these mitochondrial genes, consistent with known features of programmed translational frameshifting in the yeast TY1 and TY3 retrotransposons.
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